Melissa Ashlock
Overview
Explore the profile of Melissa Ashlock including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
1135
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0
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Recent Articles
1.
Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809
Van Goor F, Hadida S, Grootenhuis P, Burton B, Stack J, Straley K, et al.
Proc Natl Acad Sci U S A
. 2011 Oct;
108(46):18843-8.
PMID: 21976485
Cystic fibrosis (CF) is caused by mutations in the CF transmembrane conductance regulator (CFTR) gene that impair the function of CFTR, an epithelial chloride channel required for proper function of...
2.
De Boeck K, Ashlock M
Methods Mol Biol
. 2011 May;
741:3-11.
PMID: 21594774
The pilocarpine sweat test, and in vivo assessment of CFTR function via nasal potential difference or intestinal current measurement are important tools to confirm the diagnosis of CF in subjects...
3.
Solomon G, Konstan M, Wilschanski M, Billings J, Sermet-Gaudelus I, Accurso F, et al.
Chest
. 2010 May;
138(4):919-28.
PMID: 20472865
Background: The transepithelial nasal potential difference (NPD) is used to assess cystic fibrosis transmembrane conductance regulator (CFTR) activity. Unreliability, excessive artifacts, and lack of standardization of current testing systems can...
4.
Van Goor F, Hadida S, Grootenhuis P, Burton B, Cao D, Neuberger T, et al.
Proc Natl Acad Sci U S A
. 2009 Oct;
106(44):18825-30.
PMID: 19846789
Cystic fibrosis (CF) is a fatal genetic disease caused by mutations in the gene encoding the CF transmembrane conductance regulator (CFTR), a protein kinase A (PKA)-activated epithelial anion channel involved...
5.
Marshall B, Penland C, Hazle L, Ashlock M, Wetmore D, Campbell 3rd P, et al.
Respir Care
. 2009 May;
54(6):788-95.
PMID: 19467165
The Cystic Fibrosis Foundation is a voluntary, nonprofit, health organization whose mission is "to assure the development of the means to cure and control cystic fibrosis and to improve the...
6.
Mogayzel Jr P, Esmail M, Wagner T, Zeitlin P, Ashlock M
Biochim Biophys Acta
. 2002 Jun;
1576(3):306-15.
PMID: 12084577
The cystic fibrosis transmembrane conductance regulator gene (CFTR) is regulated in a tissue-specific and developmental fashion. Although it has been known for some time that phorbol esters decrease CFTR expression...