Meghann L Smith
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Explore the profile of Meghann L Smith including associated specialties, affiliations and a list of published articles.
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11
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56
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Recent Articles
1.
Almeida L, Smith M, Kamimura S, Vogel S, Quezado Z
J Physiol
. 2025 Jan;
PMID: 39775917
Circulating mature red blood cells (RBCs) from patients and mice with sickle cell disease (SCD) abnormally retain mitochondria, a factor shown to contribute to the disease's pathobiology. To further understand...
2.
Vogel S, Kamimura S, Smith M, Almeida L, Cui X, Combs C, et al.
Thromb Res
. 2024 Mar;
237:18-22.
PMID: 38547689
No abstract available.
3.
Almeida L, Smith M, Kamimura S, Vogel S, Quezado Z
Blood Cells Mol Dis
. 2023 Nov;
104:102800.
PMID: 37951090
Red blood cells (RBC) from patients with sickle cell disease (SCD) have elevated calcium levels at baseline, which are further elevated upon deoxygenation. Here we examined baseline calcium levels and...
4.
Nitrite decreases sickle hemoglobin polymerization in vitro independently of methemoglobin formation
Almeida L, Smith M, Kamimura S, Vogel S, de Souza Batista C, Quezado Z
Toxicol Appl Pharmacol
. 2023 Jun;
473:116606.
PMID: 37336294
The root cause of sickle cell disease (SCD) is the polymerization of sickle hemoglobin (HbS) leading to sickling of red blood cells (RBC). Earlier studies showed that in patients with...
5.
Vogel S, Kamimura S, Arora T, Smith M, Almeida L, Combs C, et al.
Biochem Biophys Res Commun
. 2021 Apr;
555:196-201.
PMID: 33831782
The nucleotide-binding domain leucine-rich repeat containing protein 3 (NLRP3) inflammasome is a critical inflammatory mechanism identified in platelets, which controls platelet activation and aggregation. We have recently shown that the...
6.
Khaibullina A, Almeida L, Kamimura S, Zerfas P, Smith M, Vogel S, et al.
Blood Cells Mol Dis
. 2020 Sep;
86:102493.
PMID: 32927249
Strokes are feared complications of sickle cell disease (SCD) and yield significant neurologic and neurocognitive deficits. However, even without detectable strokes, SCD patients have significant neurocognitive deficits in domains of...
7.
Lippi S, Kakalec P, Smith M, Flinn J
Front Neurosci
. 2020 Sep;
14:854.
PMID: 32922260
Alzheimer's disease (AD) is a neurocognitive disorder that impacts both the brain and behavior. Metal ions, including zinc (Zn), have been seen to play an important role in AD-related pathology....
8.
Almeida L, Wang L, Kamimura S, Zerfas P, Smith M, Neto O, et al.
Brain Res
. 2020 Jun;
1746:146968.
PMID: 32533970
Patients with sickle cell disease (SCD) can develop strokes and as a result, present neurologic and neurocognitive deficits. However, recent studies show that even without detectable cerebral parenchymal abnormalities on...
9.
Almeida L, Kamimura S, de Souza Batista C, Spornick N, Nettleton M, Walek E, et al.
Nitric Oxide
. 2019 Nov;
94:79-91.
PMID: 31689491
The hypothesis of decreased nitric oxide (NO) bioavailability in sickle cell disease (SCD) proposes that multiple factors leading to decreased NO production and increased consumption contributes to vaso-occlusion, pulmonary hypertension,...
10.
Lippi S, Smith M, Flinn J
Front Aging Neurosci
. 2018 Dec;
10:382.
PMID: 30524268
The brains of those with Alzheimer's disease have amyloid and tau pathology; thus, mice modeling AD should have both markers. In this study, we characterize offspring from the cross of...