Meghan K Eberhardt
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Explore the profile of Meghan K Eberhardt including associated specialties, affiliations and a list of published articles.
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11
Citations
242
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Recent Articles
1.
Eberhardt M, Deshpande A, Fike J, Short R, Schmidt K, Blozis S, et al.
J Virol
. 2016 Aug;
90(21):9920-9930.
PMID: 27558431
Importance: Human health is adversely impacted by viruses that establish lifelong infections that are often accompanied with increased morbidity and mortality (e.g., infections with HIV, hepatitis C virus, or human...
2.
Oxford K, Dela Pena-Ponce M, Jensen K, Eberhardt M, Spinner A, Van Rompay K, et al.
Immun Ageing
. 2015 May;
12:3.
PMID: 25991918
Background: The worldwide increase in life expectancy has been associated with an increase in age-related morbidities. The underlying mechanisms resulting in immunosenescence are only incompletely understood. Chronic viral infections, in...
3.
Eberhardt M, Barry P
Curr Top Microbiol Immunol
. 2014 Jul;
380:93-128.
PMID: 25004815
Interleukin-10 (IL-10) is a tightly regulated, pleiotropic cytokine that has profound effects on all facets of the immune system, eliciting cell-type-specific responses within cells expressing the IL-10 receptor (IL-10R). It...
4.
Eberhardt M, Deshpande A, Chang W, Barthold S, Walter M, Barry P
J Virol
. 2013 Aug;
87(21):11323-31.
PMID: 23946461
Identification of immune correlates of protection for viral vaccines is complicated by multiple factors, but there is general consensus on the importance of antibodies that neutralize viral attachment to susceptible...
5.
Eberhardt M, Chang W, Logsdon N, Yue Y, Walter M, Barry P
PLoS One
. 2012 Jun;
7(5):e37931.
PMID: 22655082
Background: Considerable evidence has accumulated that multiple viruses, bacteria, and protozoa manipulate interleukin-10 (IL-10)-mediated signaling through the IL-10 receptor (IL-10R) in ways that could enable establishment of a persistent microbial...
6.
Logsdon N, Eberhardt M, Allen C, Barry P, Walter M
PLoS One
. 2011 Dec;
6(11):e28127.
PMID: 22132227
Background: Human cytomegalovirus (HCMV) expresses a viral ortholog (CMVIL-10) of human cellular interleukin-10 (cIL-10). Despite only ∼26% amino acid sequence identity, CMVIL-10 exhibits comparable immunosuppressive activity with cIL-10, attenuates HCMV...
7.
Abel K, Strelow L, Yue Y, Eberhardt M, Schmidt K, Barry P
Vaccine
. 2008 Sep;
26(47):6013-25.
PMID: 18760319
A previous study in nonhuman primates demonstrated that genetic immunization against the rhesus cytomegalovirus phosphoprotein 65-2 (pp65-2) and glycoprotein B (gB) antigens both stimulated antigen-specific antibodies and CD8 T cell...
8.
Yue Y, Wang Z, Abel K, Li J, Strelow L, Mandarino A, et al.
Med Microbiol Immunol
. 2008 Jan;
197(2):117-23.
PMID: 18196272
A vaccine consisting of rhesus cytomegalovirus (RhCMV) pp65-2, gB and IE1 expressed via modified vaccinia Ankara (MVA) was evaluated in rhesus macaques with or without prior priming with expression plasmids...
9.
Oxford K, Eberhardt M, Yang K, Strelow L, Kelly S, Zhou S, et al.
Virology
. 2007 Dec;
373(1):181-8.
PMID: 18068749
A recent comparison of two rhesus cytomegalovirus (RhCMV) genomes revealed that the region at the right end of the U(L) genome component (U(L)b') undergoes genetic alterations similar to those observed...
10.
Chang W, Baumgarth N, Eberhardt M, Lee C, Baron C, Gregg J, et al.
J Immunol
. 2007 Jun;
178(12):7794-804.
PMID: 17548617
Dendritic cells (DC) are essential for the initiation of primary adaptive immune responses, and their functionality is strongly down-modulated by IL-10. Both innate and adaptive immune signals trigger the up-regulation...