Megha Ghildiyal
Overview
Explore the profile of Megha Ghildiyal including associated specialties, affiliations and a list of published articles.
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9
Citations
2242
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Recent Articles
1.
DeLuca S, Ghildiyal M, Pang L, Spradling A
Elife
. 2020 Aug;
9.
PMID: 32773039
Polycomb silencing represses gene expression and provides a molecular memory of chromatin state that is essential for animal development. We show that female germline stem cells (GSCs) provide a powerful...
2.
Ameres S, Horwich M, Hung J, Xu J, Ghildiyal M, Weng Z, et al.
Science
. 2010 Jun;
328(5985):1534-9.
PMID: 20558712
In Drosophila, microRNAs (miRNAs) typically guide Argonaute1 to repress messenger RNA (mRNA), whereas small interfering RNAs (siRNAs) guide Argonaute2 to destroy viral and transposon RNA. Unlike siRNAs, miRNAs rarely form...
3.
Ghildiyal M, Xu J, Seitz H, Weng Z, Zamore P
RNA
. 2009 Nov;
16(1):43-56.
PMID: 19917635
In flies, small silencing RNAs are sorted between Argonaute1 (Ago1), the central protein component of the microRNA (miRNA) pathway, and Argonaute2 (Ago2), which mediates RNA interference. Extensive double-stranded character-as is...
4.
Ghildiyal M, Zamore P
Nat Rev Genet
. 2009 Jan;
10(2):94-108.
PMID: 19148191
Since the discovery in 1993 of the first small silencing RNA, a dizzying number of small RNA classes have been identified, including microRNAs (miRNAs), small interfering RNAs (siRNAs) and Piwi-interacting...
5.
Ghildiyal M, Seitz H, Horwich M, Li C, Du T, Lee S, et al.
Science
. 2008 Apr;
320(5879):1077-81.
PMID: 18403677
Small interfering RNAs (siRNAs) direct RNA interference (RNAi) in eukaryotes. In flies, somatic cells produce siRNAs from exogenous double-stranded RNA (dsRNA) as a defense against viral infection. We identified endogenous...
6.
Seitz H, Ghildiyal M, Zamore P
Curr Biol
. 2008 Jan;
18(2):147-51.
PMID: 18207740
MicroRNAs (miRNAs) are short regulatory RNAs that direct repression of their mRNA targets. The miRNA "seed"-nucleotides 2-7-establishes target specificity by mediating target binding. Accurate processing of the miRNA 5' end...
7.
Brady M, Campellone K, Ghildiyal M, Leong J
Cell Microbiol
. 2007 May;
9(9):2242-53.
PMID: 17521329
The Tir proteins of enterohaemorrhagic and enteropathogenic Escherichia coli (EHEC and EPEC respectively) are each translocated into the host plasma membrane where they promote F-actin pedestals in epithelial cells beneath...
8.
Chopra P, Koduri H, Singh R, Koul A, Ghildiyal M, Sharma K, et al.
FEBS Lett
. 2004 Jul;
571(1-3):212-6.
PMID: 15280044
Several bacterial pathogens secrete proteins into the host cells that act as GTPase-activating proteins (GAPs) for Rho-GTPases and convert GTP-bound active form to GDP-bound inactive form. However, no such effector...
9.
Chopra P, Singh B, Singh R, Vohra R, Koul A, Meena L, et al.
Biochem Biophys Res Commun
. 2003 Oct;
311(1):112-20.
PMID: 14575702
The regulation of cellular processes by the modulation of protein phosphorylation/dephosphorylation is fundamental to a large number of processes in living organisms. These processes are carried out by specific protein...