Megan L Uhelski
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Explore the profile of Megan L Uhelski including associated specialties, affiliations and a list of published articles.
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31
Citations
505
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Recent Articles
1.
Li Y, Uhelski M, North R, Farson L, Bankston C, Roland G, et al.
Brain Behav Immun
. 2024 Oct;
123:644-655.
PMID: 39414176
Toll-like receptor 4 (TLR4) and the transient receptor potential vanilloid subtype 1 (TRPV1) are both upregulated and play key roles in the induction and expression of paclitaxel-related chemotherapy-induced peripheral neuropathy...
2.
Li Y, Uhelski M, North R, Mwirigi J, Tatsui C, McDonough K, et al.
Brain
. 2024 Jul;
147(9):2991-2997.
PMID: 39046204
Spontaneous activity in dorsal root ganglion (DRG) neurons is a key driver of neuropathic pain in patients suffering from this largely untreated disease. While many intracellular signalling mechanisms have been...
3.
Sah D, Shoffel-Havakuk H, Tsur N, Uhelski M, Gottumukkala V, Cata J
Curr Oncol
. 2024 Jun;
31(6):3086-3098.
PMID: 38920719
Pain is one of the most common symptoms in patients with cancer. Pain not only negatively affects the quality of life of patients with cancer, but it has also been...
4.
Li Y, Uhelski M, North R, Mwirigi J, Tatsui C, Cata J, et al.
bioRxiv
. 2023 Jul;
PMID: 37398249
Spontaneous activity in dorsal root ganglion (DRG) neurons is a key driver of neuropathic pain in preclinical models and in patients suffering from this largely untreated disease. While many intracellular...
5.
Adverse effects of methylene blue in peripheral neurons: An electrophysiology and cell culture study
Uhelski M, Johns M, Horrmann A, Mohamed S, Sohail A, Khasabova I, et al.
Mol Pain
. 2022 Nov;
18:17448069221142523.
PMID: 36408567
Methylene blue (MB) is an effective treatment for methemoglobinemia, ifosfamide-induced encephalopathy, cyanide poisoning, and refractory vasoplegia. However, clinical case reports and preclinical studies indicate potentially neurotoxic activity of MB at...
6.
Ray P, Shiers S, Caruso J, Tavares-Ferreira D, Sankaranarayanan I, Uhelski M, et al.
Brain
. 2022 Jul;
146(2):749-766.
PMID: 35867896
Neuropathic pain is a leading cause of high-impact pain, is often disabling and is poorly managed by current therapeutics. Here we focused on a unique group of neuropathic pain patients...
7.
Uhelski M, Gorur A, Shi T, Corrales G, Du K, Li Y, et al.
Pain Rep
. 2022 May;
7(3):e1012.
PMID: 35620249
Introduction: Currently, cancer pain is viewed as a process orchestrated by the release of pronociceptive molecules and the invasion of neural structures, referred to as perineural invasion (PNI). Cancer pain...
8.
The µ-Opioid Receptor in Cancer and Its Role in Perineural Invasion: A Short Review and New Evidence
Cata J, Uhelski M, Gorur A, Bhoir S, Ilsin N, Dougherty P
Adv Biol (Weinh)
. 2022 May;
6(9):e2200020.
PMID: 35531616
Cancer is a significant public health problem worldwide. While there has been a steady decrease in the cancer death rate over the last two decades, the number of survivors has...
9.
Cata J, Uhelski M, Gorur A, Dougherty P
Neuroscientist
. 2021 Jun;
28(4):349-363.
PMID: 34166130
The interchange of information from one cell to another relies on the release of hundreds of different molecules including small peptides, amino acids, nucleotides, RNA, steroids, retinoids, or fatty acid...
10.
Middleton S, Barry A, Comini M, Li Y, Ray P, Shiers S, et al.
Brain
. 2021 Jun;
144(5):1312-1335.
PMID: 34128530
Chronic pain affects one in five of the general population and is the third most important cause of disability-adjusted life-years globally. Unfortunately, treatment remains inadequate due to poor efficacy and...