Mayumi Hirano
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Explore the profile of Mayumi Hirano including associated specialties, affiliations and a list of published articles.
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43
Citations
353
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Recent Articles
1.
Li X, Kurahara L, Zhao Z, Zhao F, Ishikawa R, Ohmichi K, et al.
Cell Mol Gastroenterol Hepatol
. 2024 Apr;
18(1):105-131.
PMID: 38614455
Background & Aims: Inflammatory bowel disease is associated with carcinogenesis, which limits the prognosis of the patients. The local expression of proteinases and proteinase-activated receptor 1 (PAR) increases in inflammatory...
2.
Hirano M, Hirano K
J Physiol Sci
. 2022 Dec;
72(1):32.
PMID: 36476233
We previously reported the Rho-associated coiled-coil containing protein kinase (ROCK)-mediated di-phosphorylation of myosin light chain (MLC) and actin bundle formation at the cell periphery as early events of the endothelial...
3.
Igarashi-Hisayoshi Y, Ihara E, Bai X, Higashi C, Ikeda H, Tanaka Y, et al.
Dig Dis Sci
. 2022 Aug;
68(2):439-450.
PMID: 35947306
Background: The specific role of the M muscarinic acetylcholine receptor in gastrointestinal motility under physiological conditions is unclear, due to a lack of subtype-selective compounds. Aims: The objective of this...
4.
Watanabe T, Ishikawa M, Abe K, Ishikawa T, Imakiire S, Masaki K, et al.
J Am Heart Assoc
. 2021 Nov;
10(23):e022712.
PMID: 34845934
Background Recent studies have demonstrated that uric acid (UA) enhances arginase activity, resulting in decreased NO in endothelial cells. However, the role of lung UA in pulmonary arterial hypertension (PAH)...
5.
Ishikawa T, Abe K, Takana-Ishikawa M, Yoshida K, Watanabe T, Imakiire S, et al.
J Am Heart Assoc
. 2021 Mar;
10(7):e019247.
PMID: 33787285
Background Recent accumulating evidence suggests that toll-like receptor 9 (TLR9) is involved in the pathogenesis of cardiovascular diseases. However, its role in pulmonary hypertension remains uncertain. We hypothesized that TLR9...
6.
Bai X, Ihara E, Otsuka Y, Tsuruta S, Hirano K, Tanaka Y, et al.
Eur J Pharmacol
. 2019 May;
857:172405.
PMID: 31128092
Prostaglandin E (PGE) plays a role in the pathogenesis of gastro-esophageal reflux disease (GERD). There are 4 subtypes of PGE, PGE receptor 1, 2, 3 and 4 (EP 1-4). In...
7.
Kuwabara Y, Tanaka-Ishikawa M, Abe K, Hirano M, Hirooka Y, Tsutsui H, et al.
Cardiovasc Res
. 2018 Nov;
115(8):1357-1368.
PMID: 30423156
Aims: Pulmonary hypertension (PH) is characterized by progressive increases in pulmonary vascular resistance (PVR). Thrombotic lesions are common pathological findings. The pulmonary artery has a unique property regarding the vasoconstrictive...
8.
Bai X, Ihara E, Hirano K, Tanaka Y, Nakano K, Kita S, et al.
Cell Mol Gastroenterol Hepatol
. 2018 Jan;
5(3):209-221.
PMID: 29379856
Background And Aims: Hydrogen sulfide (HS) is a major physiologic gastrotransmitter. Its role in the regulation of the lower esophageal sphincter (LES) function remains unknown. The present study addresses this...
9.
Xiaopeng B, Tanaka Y, Ihara E, Hirano K, Nakano K, Hirano M, et al.
Eur J Pharmacol
. 2017 Jan;
797:65-74.
PMID: 28088386
Duodenal reflux of fluids containing trypsin relates to refractory gastroesophageal reflux disease (GERD). Esophageal peristalsis and clearance are important factors in GERD pathogenesis. However, the function of trypsin in esophageal...
10.
Hirano M, Hirano K
Sci Rep
. 2016 Feb;
6:20989.
PMID: 26863988
The phosphorylation of the 20-kD myosin light chain (MLC) and actin filament formation play a key role in endothelial barrier disruption. MLC is either mono- or di-phosphorylated (pMLC and ppMLC)...