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Maximiliano Rojas

Explore the profile of Maximiliano Rojas including associated specialties, affiliations and a list of published articles. Areas
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Articles 12
Citations 78
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Recent Articles
1.
Opazo M, Yanez O, Marquez-Miranda V, Santos J, Rojas M, Araya-Duran I, et al.
Int J Mol Sci . 2024 Jun; 25(11). PMID: 38892021
Thyroxine (T4) is a drug extensively utilized for the treatment of hypothyroidism. However, the oral absorption of T4 presents certain limitations. This research investigates the efficacy of CO nanobubbles in...
2.
Salgado M, Marquez-Miranda V, Ferrada L, Rojas M, Poblete-Flores G, Gonzalez-Nilo F, et al.
Proc Natl Acad Sci U S A . 2024 Jun; 121(25):e2405468121. PMID: 38861601
Pannexin1 hemichannels (Panx1 HCs) are found in the membrane of most mammalian cells and communicate the intracellular and extracellular spaces, enabling the passive transfer of ions and small molecules. They...
3.
Carrasquel-Ursulaez W, Segura I, Diaz-Franulic I, Echeverria F, Lorenzo-Ceballos Y, Espinoza N, et al.
Proc Natl Acad Sci U S A . 2022 Jun; 119(25):e2204620119. PMID: 35704760
In neurosecretion, allosteric communication between voltage sensors and Ca binding in BK channels is crucially involved in damping excitatory stimuli. Nevertheless, the voltage-sensing mechanism of BK channels is still under...
4.
Palacios-Prado N, Soto P, Lopez X, Choi E, Marquez-Miranda V, Rojas M, et al.
Proc Natl Acad Sci U S A . 2022 Apr; 119(18):e2202104119. PMID: 35486697
The occurrence of intercellular channels formed by pannexin1 has been challenged for more than a decade. Here, we provide an electrophysiological characterization of exogenous human pannexin1 (hPanx1) cell–cell channels expressed...
5.
Gil-Duran C, Sepulveda R, Rojas M, Castro-Fernandez V, Guixe V, Vaca I, et al.
Int J Mol Sci . 2022 Feb; 23(4). PMID: 35216436
Endoxylanases belonging to family 10 of the glycoside hydrolases (GH10) are versatile in the use of different substrates. Thus, an understanding of the molecular mechanisms underlying substrate specificities could be...
6.
Guiza J, Garcia A, Arriagada J, Gutierrez C, Gonzalez J, Marquez-Miranda V, et al.
J Cell Physiol . 2021 Nov; 237(2):1547-1560. PMID: 34779505
Large-pore channels, including those formed by connexin, pannexin, innexin proteins, are part of a broad family of plasma membrane channels found in vertebrates and invertebrates, which share topology features. Despite...
7.
Lopez X, Palacios-Prado N, Guiza J, Escamilla R, Fernandez P, Vega J, et al.
Proc Natl Acad Sci U S A . 2021 Jul; 118(32). PMID: 34301850
Pannexin1 (Panx1) channels are ubiquitously expressed in vertebrate cells and are widely accepted as adenosine triphosphate (ATP)-releasing membrane channels. Activation of Panx1 has been associated with phosphorylation in a specific...
8.
Duarte Y, Rojas M, Canan J, Perez E, Gonzalez-Nilo F, Garcia-Colunga J
Molecules . 2021 Mar; 26(4). PMID: 33668529
Several antidepressants inhibit nicotinic acetylcholine receptors (nAChRs) in a non-competitive and voltage-dependent fashion. Here, we asked whether antidepressants with a different structure and pharmacological profile modulate the rat α7 nAChR...
9.
Marquez-Miranda V, Rojas M, Duarte Y, Diaz-Franulic I, Holmgren M, Cachau R, et al.
bioRxiv . 2020 Oct; PMID: 33106803
SARS-CoV-2 ORF3a is believed to form ion channels, which may be involved in the modulation of virus release, and has been implicated in various cellular processes like the up-regulation of...
10.
Hinostroza F, Neely A, Araya-Duran I, Maraboli V, Canan J, Rojas M, et al.
Sci Rep . 2020 Oct; 10(1):18151. PMID: 33097808
High order oligomers are crucial for normal cell physiology, and protein function perturbed by missense mutations underlies several autosomal dominant diseases. Dynamin-2 is one of such protein forming helical oligomers...