Mauricio P Contreras
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Explore the profile of Mauricio P Contreras including associated specialties, affiliations and a list of published articles.
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15
Citations
315
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Recent Articles
1.
Madhuprakash J, Toghani A, Contreras M, Posbeyikian A, Richardson J, Kourelis J, et al.
Sci Adv
. 2024 Nov;
10(45):eadr2594.
PMID: 39504373
NRCs are essential helper NLR (nucleotide-binding domain and leucine-rich repeat) proteins that execute immune responses triggered by sensor NLRs. The resting state of NbNRC2 was recently shown to be a...
2.
Selvaraj M, Toghani A, Pai H, Sugihara Y, Kourelis J, Yuen E, et al.
PLoS Biol
. 2024 Oct;
22(10):e3002868.
PMID: 39423240
Nucleotide-binding domain and leucine-rich repeat (NLR) proteins can engage in complex interactions to detect pathogens and execute a robust immune response via downstream helper NLRs. However, the biochemical mechanisms of...
3.
Sakai T, Contreras M, Martinez-Anaya C, Ludke D, Kamoun S, Wu C, et al.
Plant Cell
. 2024 Jun;
36(9):3344-3361.
PMID: 38833594
Nucleotide-binding domain and leucine-rich repeat-containing receptor (NLR) proteins can form complex receptor networks to confer innate immunity. An NLR-REQUIRED FOR CELL DEATH (NRC) is a phylogenetically related node that functions...
4.
Contreras M, Pai H, Thompson R, Marchal C, Claeys J, Adachi H, et al.
New Phytol
. 2024 May;
243(1):345-361.
PMID: 38757730
Nucleotide-binding domain and leucine-rich repeat (NLR) proteins with pathogen sensor activities have evolved to initiate immune signaling by activating helper NLRs. However, the mechanisms underpinning helper NLR activation by sensor...
5.
Contreras M, Ludke D, Pai H, Toghani A, Kamoun S
EMBO Rep
. 2023 Aug;
24(10):e57495.
PMID: 37602936
Plants coordinately use cell-surface and intracellular immune receptors to perceive pathogens and mount an immune response. Intracellular events of pathogen recognition are largely mediated by immune receptors of the nucleotide...
6.
Contreras M, Pai H, Selvaraj M, Toghani A, Lawson D, Tumtas Y, et al.
Sci Adv
. 2023 May;
9(18):eadg3861.
PMID: 37134163
Parasites counteract host immunity by suppressing helper nucleotide binding and leucine-rich repeat (NLR) proteins that function as central nodes in immune receptor networks. Understanding the mechanisms of immunosuppression can lead...
7.
Sugihara Y, Abe Y, Takagi H, Abe A, Shimizu M, Ito K, et al.
PLoS Biol
. 2023 Jan;
21(1):e3001945.
PMID: 36656825
Studies focused solely on single organisms can fail to identify the networks underlying host-pathogen gene-for-gene interactions. Here, we integrate genetic analyses of rice (Oryza sativa, host) and rice blast fungus...
8.
Ahn H, Lin X, Olave-Achury A, Derevnina L, Contreras M, Kourelis J, et al.
EMBO J
. 2023 Jan;
42(5):e111484.
PMID: 36592032
Plant pathogens compromise crop yields. Plants have evolved robust innate immunity that depends in part on intracellular Nucleotide-binding, Leucine rich-Repeat (NLR) immune receptors that activate defense responses upon detection of...
9.
Contreras M, Pai H, Tumtas Y, Duggan C, Yuen E, Cruces A, et al.
EMBO J
. 2022 Dec;
42(5):e111519.
PMID: 36579501
Nucleotide-binding domain leucine-rich repeat (NLR) immune receptors are important components of plant and metazoan innate immunity that can function as individual units or as pairs or networks. Upon activation, NLRs...
10.
Kourelis J, Contreras M, Harant A, Pai H, Ludke D, Adachi H, et al.
PLoS Genet
. 2022 Sep;
18(9):e1010414.
PMID: 36137148
Cell surface pattern recognition receptors (PRRs) activate immune responses that can include the hypersensitive cell death. However, the pathways that link PRRs to the cell death response are poorly understood....