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Maurice Mbewe

Explore the profile of Maurice Mbewe including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 13
Citations 178
Followers 0
Related Specialties
Infectious Diseases
General Medicine
Biotechnology
Top 10 Co-Authors
James E Meiring
Melita A Gordon
Robert S Heyderman
Melita Gordon
Priyanka D Patel
Pratiksha Patel
Deus Thindwa
Happy Banda
Innocent Kadwala
Neil French
Published In
EMBO Mol Med
J Infect Dis
Lancet Infect Dis
BMC Infect Dis
Wellcome Open Res
Affiliations
Soon will be listed here.
Recent Articles
1.
Understanding the epidemiology of iNTS disease in Africa in preparation for future iNTS- vaccine studies in endemic countries: Seroepidemiology in Africa of iNTS (SAiNTS) Study Protocol: Malawi site [Version 9.0]
Dale H, Chirwa E, Patel P, Makuta G, Mwakiseghile F, Misiri T, et al.
Wellcome Open Res . 2024 Aug; 8:27. PMID: 39183741
Background: Non-typhoidal Salmonella (NTS) are a major cause of bloodstream infections amongst children in sub-Saharan Africa. A clear understanding of the seroepidemiology and correlates of protection for invasive NTS (iNTS)...
2.
Evaluating the relationship between ciprofloxacin prescription and non-susceptibility in Salmonella Typhi in Blantyre, Malawi: an observational study
Ashton P, Chunga Chirambo A, Meiring J, Patel P, Mbewe M, Silungwe N, et al.
Lancet Microbe . 2024 Feb; 5(3):e226-e234. PMID: 38387472
Background: Ciprofloxacin is the first-line drug for treating typhoid fever in many countries in Africa with a high disease burden, but the emergence of non-susceptibility poses a challenge to public...
3.
Characterization of Enzyme-Linked Immunosorbent Assay (ELISA) for Quantification of Antibodies against Typhimurium and Enteritidis O-Antigens in Human Sera
Aruta M, Lari E, De Simone D, Semplici B, Semplici C, Dale H, et al.
BioTech (Basel) . 2023 Aug; 12(3). PMID: 37606441
Nontyphoidal Salmonella (NTS) is a leading cause of morbidity and mortality caused by enteric pathogens worldwide in both children and adults, and vaccines are not yet available. The measurement of...
4.
Bacterial shedding and serologic responses following an outbreak of Salmonella Typhi in an endemic cohort
Johnston P, Bogue P, Chunga Chirambo A, Mbewe M, Prakash R, Kandoole-Kabwere V, et al.
BMC Infect Dis . 2023 Jun; 23(1):416. PMID: 37340341
Background: Salmonella enterica serovar Typhi (Salmonella Typhi) is the cause of typhoid fever. Salmonella Typhi may be transmitted through shedding in the stool, which can continue after recovery from acute...
5.
Development and Characterization of a Luminescence-Based High-Throughput Serum Bactericidal Assay (L-SBA) to Assess Bactericidal Activity of Human Sera against Nontyphoidal
Aruta M, De Simone D, Dale H, Chirwa E, Kadwala I, Mbewe M, et al.
Methods Protoc . 2022 Dec; 5(6). PMID: 36548142
Typhimurium and Enteritidis are leading causative agents of invasive nontyphoidal (iNTS) disease, which represents one of the major causes of death and morbidity in sub-Saharan Africa, still partially underestimated. Large...
6.
Quality of antibody responses by adults and young children to 13-valent pneumococcal conjugate vaccination and Streptococcus pneumoniae colonisation
Wolf A, Mitsi E, Jones S, Jochems S, Roalfe L, Thindwa D, et al.
Vaccine . 2022 Oct; 40(50):7201-7210. PMID: 36210249
Childhood pneumococcal conjugate vaccine (PCV) protects against invasive pneumococcal disease caused by vaccine-serotype (VT) Streptococcus pneumoniae by generating opsonophagocytic anti-capsular antibodies, but how vaccination protects against and reduces VT carriage...
7.
Waning of antibody levels induced by a 13-valent pneumococcal conjugate vaccine, using a 3 + 0 schedule, within the first year of life among children younger than 5 years in Blantyre, Malawi: an observational, population-level, serosurveillance...
Swarthout T, Henrion M, Thindwa D, Meiring J, Mbewe M, Kalizangoma A, et al.
Lancet Infect Dis . 2022 Aug; 22(12):1737-1747. PMID: 36029796
Background: Pneumococcal conjugate vaccines (PCVs) induce serotype-specific IgG antibodies, effectively reducing vaccine-serotype carriage and invasive pneumococcal disease (IPD). IgG production wanes approximately 1 month after vaccination in absence of serotype-specific...
8.
Safety and immunogenicity of a typhoid conjugate vaccine among children aged 9 months to 12 years in Malawi: a nested substudy of a double-blind, randomised controlled trial
Nampota-Nkomba N, Nyirenda O, Khonde L, Mapemba V, Mbewe M, Ndaferankhande J, et al.
Lancet Glob Health . 2022 Aug; 10(9):e1326-e1335. PMID: 35961356
Background: Typhoid fever is a substantial public health problem in Africa, yet there are few clinical trials of typhoid conjugate vaccine (TCV). We assessed immunogenicity and safety of Typbar TCV...
9.
A clinical and molecular epidemiological survey of hepatitis C in Blantyre, Malawi, suggests a historic mechanism of transmission
Stockdale A, Kreuels B, Shawa I, Meiring J, Thindwa D, Silungwe N, et al.
J Viral Hepat . 2022 Jan; 29(4):252-262. PMID: 35075742
Hepatitis C virus (HCV) is a leading cause of liver disease worldwide. There are no previous representative community HCV prevalence studies from Southern Africa, and limited genotypic data. Epidemiological data...
10.
Hepatitis B Vaccination Impact and the Unmet Need for Antiviral Treatment in Blantyre, Malawi
Stockdale A, Meiring J, Shawa I, Thindwa D, Silungwe N, Mbewe M, et al.
J Infect Dis . 2021 Nov; 226(5):871-880. PMID: 34752631
Background: Hepatitis B is the leading cause of cirrhosis and liver cancer in sub-Saharan Africa. To reduce mortality, antiviral treatment programs are needed. We estimated prevalence, vaccine impact, and need...