Maud M Koek
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Explore the profile of Maud M Koek including associated specialties, affiliations and a list of published articles.
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7
Citations
226
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Recent Articles
1.
Koek M, Jellema R, van der Greef J, Tas A, Hankemeier T
Metabolomics
. 2011 Sep;
7(3):307-328.
PMID: 21949491
Metabolomics involves the unbiased quantitative and qualitative analysis of the complete set of metabolites present in cells, body fluids and tissues (the metabolome). By analyzing differences between metabolomes using biostatistics...
2.
Koek M, van der Kloet F, Kleemann R, Kooistra T, Verheij E, Hankemeier T
Metabolomics
. 2011 Apr;
7(1):1-14.
PMID: 21461033
Due to the complexity of typical metabolomics samples and the many steps required to obtain quantitative data in GC × GC-MS consisting of deconvolution, peak picking, peak merging, and integration,...
3.
Koek M, Bakels F, Engel W, van den Maagdenberg A, Ferrari M, Coulier L, et al.
Anal Chem
. 2009 Dec;
82(1):156-62.
PMID: 19947586
Profiling of metabolites is increasingly used to study the functioning of biological systems. For some studies the volume of available samples is limited to only a few microliters or even...
4.
Comprehensive analysis of the metabolome of Pseudomonas putida S12 grown on different carbon sources
van der Werf M, Overkamp K, Muilwijk B, Koek M, van der Werff-van der Vat B, Jellema R, et al.
Mol Biosyst
. 2008 Mar;
4(4):315-27.
PMID: 18354785
Metabolomics is an emerging, powerful, functional genomics technology that involves the comparative non-targeted analysis of the complete set of metabolites in an organism. We have set-up a robust quantitative metabolomics...
5.
Koek M, Muilwijk B, van Stee L, Hankemeier T
J Chromatogr A
. 2007 Dec;
1186(1-2):420-9.
PMID: 18155223
A major challenge in metabolomics analysis is the accurate quantification of metabolites in the presence of (extremely) high abundant metabolites. Quantification of metabolites at low concentrations can be complicated by...
6.
Chang W, Thissen U, Ehlert K, Koek M, Jellema R, Hankemeier T, et al.
Planta Med
. 2006 Mar;
72(5):458-67.
PMID: 16557461
Metabolite profiling in combination with multivariate statistics is a sophisticated method for quality assessment of natural products. For the development of a quality control strategy in Traditional Chinese Medicine (TCM),...
7.
Koek M, Muilwijk B, van der Werf M, Hankemeier T
Anal Chem
. 2006 Feb;
78(4):1272-81.
PMID: 16478122
An analytical method was set up suitable for the analysis of microbial metabolomes, consisting of an oximation and silylation derivatization reaction and subsequent analysis by gas chromatography coupled to mass...