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Matthias W Laschke

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Articles 296
Citations 3634
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Recent Articles
1.
Englisch C, Diebolt C, Kirstein E, Wahl V, Wartenberg P, Schaudien D, et al.
Naunyn Schmiedebergs Arch Pharmacol . 2025 Mar; PMID: 40025338
Magnesium is the fourth most abundant cation in the human organism. As a key-player in many enzymatic reactions, magnesium homeostasis disbalance can cause severe disorders. In the early 2000s, the...
2.
Gu Y, Tang T, Qiu M, Wang H, Ampofo E, Menger M, et al.
Angiogenesis . 2025 Feb; 28(2):13. PMID: 39899169
Inhibition of angiogenesis, either as monotherapy or in conjunction with other treatments, holds significant promise in cancer treatment. However, the limited efficacy of clinically approved anti-angiogenic agents underscores the urgent...
3.
Hollander S, von Heesen M, Gabelein G, Mercier J, Laschke M, Menger M, et al.
Sci Rep . 2025 Jan; 15(1):2753. PMID: 39843785
Cilostazol has previously been shown to reduce liver steatosis and enhance hepatic perfusion. We investigated the effects of cilostazol after major hepatectomy in a steatotic rat model. Six weeks prior...
4.
Scherschel M, Niemeier J, Jacobs L, Hoffmann M, Diederich A, Bell C, et al.
Nat Commun . 2024 Dec; 15(1):10704. PMID: 39702652
The NADPH/NADP redox couple is central to metabolism and redox signalling. NADP redox state is differentially regulated by distinct enzymatic machineries at the subcellular compartment level. Nonetheless, a detailed understanding...
5.
Walle N, Dings C, Zaher O, Doerr A, Peters B, Laschke M, et al.
Arch Toxicol . 2024 Dec; 99(2):633-643. PMID: 39630204
Synthetic cannabinoids (SCs) are consumed as an alternative to cannabis. Novel compounds are developed by minor modifications in their chemical structure, e.g. insertion of a carboxamide moiety as a linker,...
6.
Doerr A, Dings C, Zaher O, Nordmeier F, Walle N, Laschke M, et al.
Br J Clin Pharmacol . 2024 Nov; PMID: 39569436
Aims: Since their emergence on the drug market, synthetic cannabinoids (SC) are still gaining increasing importance in forensic toxicology. The representatives of the so-called new psychoactive substances have in common...
7.
Menger M, Speicher R, Hans S, Histing T, El Kayali M, Ehnert S, et al.
Int J Mol Sci . 2024 Nov; 25(21). PMID: 39519338
Inflammation has been recognized as major factor for successful bone regeneration. On the other hand, a prolonged or overshooting inflammatory response can also cause fracture healing failure. The nucleotide-binding oligomerization...
8.
Bonomi F, Limido E, Weinzierl A, Ampofo E, Harder Y, Menger M, et al.
J Funct Biomater . 2024 Oct; 15(10). PMID: 39452592
Dermal substitutes require sufficient tissue integration and vascularization to be successfully covered with split-thickness skin grafts. To rapidly achieve this, we provide the proof of principle for a novel vascularization...
9.
Walle N, Doerr A, Peters B, Laschke M, Menger M, Schmidt P, et al.
Toxicol Lett . 2024 Oct; 401:170-180. PMID: 39395683
The number of fatal cases involving synthetic cannabinoids (SCs) is increasing. However, interpretation of postmortem (PM) toxicological findings is challenging, due to unknown PM intervals and possible redistribution processes or...
10.
Thull R, Goedicke-Fritz S, Schmiech D, Marnach A, Muller S, Korbel C, et al.
Biosensors (Basel) . 2024 Sep; 14(9). PMID: 39329812
(1) Objective: This study aims to lay a foundation for noncontact intensive care monitoring of premature babies. (2) Methods: Arterial oxygen saturation and heart rate were measured using a monochrome...