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Matthias Van Gils

Explore the profile of Matthias Van Gils including associated specialties, affiliations and a list of published articles. Areas
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Articles 12
Citations 94
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Recent Articles
1.
Van Gils M, Depauw J, Coucke P, Aerts S, Verschuere S, Nollet L, et al.
J Clin Med . 2023 Mar; 12(5). PMID: 36902680
Pseudoxanthoma elasticum (PXE) is a rare ectopic calcification disorder affecting soft connective tissues that is caused by biallelic mutations. While the underlying pathomechanisms are incompletely understood, reduced circulatory levels of...
2.
Nollet L, Van Gils M, Fischer S, Campens L, Karthik S, Pasch A, et al.
J Clin Med . 2022 Jul; 11(13). PMID: 35807012
Pseudoxanthoma elasticum (PXE) is a currently intractable genetic disorder characterized by progressive ectopic calcification in the skin, eyes and arteries. Therapeutic trials in PXE are severely hampered by the lack...
3.
Nollet L, Van Gils M, Willaert A, Coucke P, Vanakker O
J Invest Dermatol . 2021 Nov; 142(6):1629-1638.e6. PMID: 34742705
Pseudoxanthoma elasticum (PXE) is a hereditary ectopic calcification disorder affecting the skin, eyes, and blood vessels. Recently, the DNA damage response (DDR), in particular PARP1, was shown to be involved...
4.
Ibold B, Tiemann J, Faust I, Ceglarek U, Dittrich J, Gorgels T, et al.
Sci Rep . 2021 Jan; 11(1):2137. PMID: 33483533
Genetic studies link adenosine triphosphate-binding cassette transporter C6 (ABCC6) mutations to pseudoxanthoma elasticum (PXE). ABCC6 sequence variations are correlated with altered HDL cholesterol levels and an elevated risk of coronary...
5.
De Clercq E, Van Gils M, Schautteet K, Devriendt B, Kiekens C, Chiers K, et al.
Front Immunol . 2020 Nov; 11:555305. PMID: 33193323
The current study was designed to evaluate the pathogenesis, pathology and immune response of female genital tract infection with L2c, the most recently discovered lymphogranuloma venereum strain, using a porcine...
6.
Verschuere S, Van Gils M, Nollet L, Vanakker O
FEBS Lett . 2020 Nov; 594(23):4109-4133. PMID: 33131056
ATP-binding cassette subfamily C member 6 gene/protein (ABCC6) is an ATP-dependent transmembrane transporter predominantly expressed in the liver and the kidney. ABCC6 first came to attention in human medicine when...
7.
Tiemann J, Wagner T, Vanakker O, Van Gils M, Cabrera J, Ibold B, et al.
Aging Dis . 2020 Jun; 11(3):536-546. PMID: 32489700
The molecular processes of aging are very heterogenic and not fully understood. Studies on rare progeria syndromes, which display an accelerated progression of physiological aging, can help to get a...
8.
Kiss N, Fesus L, Bozsanyi S, Szeri F, Van Gils M, Szabo V, et al.
Lasers Med Sci . 2020 May; 35(8):1821-1830. PMID: 32372237
Pseudoxanthoma elasticum (PXE, OMIM 264800) is a rare autosomal recessive disorder with ectopic mineralization and fragmentation of elastin fibers. It is caused by mutations of the ABCC6 gene that leads...
9.
Sanchez-Tevar A, Garcia-Fernandez M, Murcia-Casas B, Rioja-Villodres J, Carrillo J, Camacho M, et al.
Ann Transl Med . 2020 Feb; 7(24):798. PMID: 32042814
Background: Inorganic pyrophosphate (PPi) plays a major role inhibiting dystrophic calcification. The aim was to analyze levels of PPi in patients having pseudoxanthoma elasticum (PXE), and controls as well as...
10.
Nollet L, Van Gils M, Verschuere S, Vanakker O
Int J Mol Sci . 2019 May; 20(9). PMID: 31052252
Ectopic mineralization disorders comprise a broad spectrum of inherited or acquired diseases characterized by aberrant deposition of calcium crystals in multiple organs, such as the skin, eyes, kidneys, and blood...