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Matthias Schlensak

Explore the profile of Matthias Schlensak including associated specialties, affiliations and a list of published articles. Areas
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Articles 17
Citations 724
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Recent Articles
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Kahl S, Strassburger K, Pacini G, Trinks N, Pafili K, Mastrototaro L, et al.
J Hepatol . 2024 Sep; 82(3):417-426. PMID: 39218222
Background & Aims: Hepatic mitochondrial respiration is higher in steatosis, but lower in overt type 2 diabetes. We hypothesized that hepatic oxidative phosphorylation (OXPHOS) capacity increases with a greater degree...
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Kovac L, Gancheva S, Jahnert M, Sehgal R, Mastrototaro L, Schlensak M, et al.
Diabetes Metab . 2024 Jul; 50(5):101561. PMID: 38977261
Aim: Bariatric surgery is highly effective for the treatment of obesity in individuals without (OB) and in those with type 2 diabetes (T2D). However, whether bariatric surgery triggers similar or...
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Sarabhai T, Kahl S, Gancheva S, Mastrototaro L, Dewidar B, Pesta D, et al.
Metabolism . 2023 Dec; 151:155762. PMID: 38122893
Background: Obesity and type 2 diabetes frequently have metabolic dysfunction-associated steatotic liver disease (MASLD) including steatohepatitis (MASH). In obesity, the liver may adapt its oxidative capacity, but the role of...
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Gancheva S, Kahl S, Herder C, Strassburger K, Sarabhai T, Pafili K, et al.
Int J Obes (Lond) . 2023 Mar; 47(6):505-511. PMID: 36959287
Aims: Body weight loss improves insulin resistance and growth hormone secretion in obesity, which may be regulated by leptin according to preclinical studies. How changes in leptin, lipids and insulin...
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Pafili K, Kahl S, Mastrototaro L, Strassburger K, Pesta D, Herder C, et al.
J Hepatol . 2022 Aug; 77(6):1504-1514. PMID: 35988689
Background & Aims: Adipose tissue dysfunction is involved in the development of insulin resistance and is responsible for excessive lipid delivery to other organs such as the liver. We tested...
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Gancheva S, Ouni M, Jelenik T, Koliaki C, Szendroedi J, Toledo F, et al.
Nat Commun . 2022 Jun; 13(1):3353. PMID: 35688803
No abstract available.
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Gancheva S, Kahl S, Pesta D, Mastrototaro L, Dewidar B, Strassburger K, et al.
Diabetes Care . 2022 Feb; 45(4):928-937. PMID: 35113139
Objective: Individuals with type 2 diabetes are at higher risk of progression of nonalcoholic fatty liver (steatosis) to steatohepatitis (NASH), fibrosis, and cirrhosis. The hepatic metabolism of obese individuals adapts...
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Apostolopoulou M, Gordillo R, Gancheva S, Strassburger K, Herder C, Esposito I, et al.
BMJ Open Diabetes Res Care . 2020 Nov; 8(2). PMID: 33219119
Introduction: Sphingolipid accumulation has been linked to obesity, type 2 diabetes and non-alcoholic fatty liver disease (NAFLD). A recent study showed that depletion of dihydroceramide desaturase-1 (DES-1) in adipose and/or...
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Gancheva S, Ouni M, Jelenik T, Koliaki C, Szendroedi J, Toledo F, et al.
Nat Commun . 2019 Sep; 10(1):4179. PMID: 31519890
The mechanisms underlying improved insulin sensitivity after surgically-induced weight loss are still unclear. We monitored skeletal muscle metabolism in obese individuals before and over 52 weeks after metabolic surgery. Initial...