Matthias Sammer
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Explore the profile of Matthias Sammer including associated specialties, affiliations and a list of published articles.
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14
Citations
78
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Recent Articles
1.
Rudigkeit S, Schmid T, Dombrowsky A, Stolz J, Bartzsch S, Chen C, et al.
Sci Rep
. 2024 Jan;
14(1):1418.
PMID: 38228747
FLASH-radiotherapy may provide significant sparing of healthy tissue through ultra-high dose rates in protons, electrons, and x-rays while maintaining the tumor control. Key factors for the FLASH effect might be...
2.
Schwarz B, Matejka N, Rudigkeit S, Sammer M, Reindl J
Int J Mol Sci
. 2024 Jan;
25(1).
PMID: 38203799
Ion-radiation-induced DNA double-strand breaks can lead to severe cellular damage ranging from mutations up to direct cell death. The interplay between the chromatin surrounding the damage and the proteins responsible...
3.
Sammer M, Rousseti A, Girst S, Reindl J, Dollinger G
Cancers (Basel)
. 2022 Oct;
14(20).
PMID: 36291946
The prerequisite of any radiation therapy modality (X-ray, electron, proton, and heavy ion) is meant to meet at least a minimum prescribed dose at any location in the tumor for...
4.
Scherthan H, Wagner S, Grundhofer J, Matejka N, Muller J, Muller S, et al.
Cancers (Basel)
. 2022 Mar;
14(6).
PMID: 35326696
: High doses of ionizing radiation in radiotherapy can elicit undesirable side effects to the skin. Proton minibeam radiotherapy (pMBRT) may circumvent such limitations due to tissue-sparing effects observed at...
5.
Rudigkeit S, Reindl J, Matejka N, Ramson R, Sammer M, Dollinger G, et al.
Front Oncol
. 2021 Jul;
11:688333.
PMID: 34277433
The fundamental basis in the development of novel radiotherapy methods is cellular studies. To assess different endpoints of cellular reactions to irradiation like proliferation, cell cycle arrest, and cell death,...
6.
Sammer M, Girst S, Dollinger G
Sci Rep
. 2021 Feb;
11(1):3533.
PMID: 33574390
Proton minibeam radiotherapy (pMBRT) is a spatial fractionation method using sub-millimeter beams at center-to-center (ctc) distances of a few millimeters to widen the therapeutic index by reduction of side effects...
7.
Friedrich T, Ilicic K, Greubel C, Girst S, Reindl J, Sammer M, et al.
Sci Rep
. 2020 Nov;
10(1):19552.
PMID: 33154512
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
8.
Sammer M, Dombrowsky A, Schauer J, Oleksenko K, Bicher S, Schwarz B, et al.
Int J Radiat Oncol Biol Phys
. 2020 Aug;
109(1):76-83.
PMID: 32805301
Purpose: Proton minibeam radiation therapy, a spatial fractionation concept, widens the therapeutic window. By reducing normal tissue toxicities, it allows a temporally fractionated regime with high daily doses. However, an...
9.
Sammer M, Zahnbrecher E, Dobiasch S, Girst S, Greubel C, Ilicic K, et al.
PLoS One
. 2019 Nov;
14(11):e0224873.
PMID: 31765436
Proton radiotherapy using minibeams of sub-millimeter dimensions reduces side effects in comparison to conventional proton therapy due to spatial fractionation. Since the proton minibeams widen with depth, the homogeneous irradiation...
10.
Siebenwirth C, Greubel C, Drexler G, Reindl J, Walsh D, Schwarz B, et al.
J Cell Sci
. 2019 Sep;
132(19).
PMID: 31492757
Nucleoli have attracted interest for their role as cellular stress sensors and as potential targets for cancer treatment. The effect of DNA double-strand breaks (DSBs) in nucleoli on rRNA transcription...