Matthias Gutekunst
Overview
Explore the profile of Matthias Gutekunst including associated specialties, affiliations and a list of published articles.
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6
Citations
340
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Recent Articles
1.
Davies E, Dong M, Gutekunst M, Narhi K, van Zoggel H, Blom S, et al.
Sci Rep
. 2015 Dec;
5:17187.
PMID: 26647838
Precision-cut slices of in vivo tumours permit interrogation in vitro of heterogeneous cells from solid tumours together with their native microenvironment. They offer a low throughput but high content in...
2.
Hickman J, Graeser R, De Hoogt R, Vidic S, Brito C, Gutekunst M, et al.
Biotechnol J
. 2014 Sep;
9(9):1115-28.
PMID: 25174503
Cancers are complex and heterogeneous pathological "organs" in a dynamic interplay with their host. Models of human cancer in vitro, used in cancer biology and drug discovery, are generally highly...
3.
Gutekunst M, Mueller T, Weilbacher A, Dengler M, Bedke J, Kruck S, et al.
Cancer Res
. 2013 Jan;
73(5):1460-9.
PMID: 23302226
Testicular germ cell tumors (TGCT) are considered a paradigm of chemosensitive tumors. Embryonal carcinoma cells represent the pluripotent entity of TGCTs and are characterized by expression of Oct-4, a key...
4.
Dengler M, Staiger A, Gutekunst M, Hofmann U, Doszczak M, Scheurich P, et al.
PLoS One
. 2011 Sep;
6(9):e25139.
PMID: 21949869
In response to deregulated oncogene activation, mammalian cells activate disposal programs such as programmed cell death. To investigate the mechanisms behind this oncogenic stress response we used Bcr-Abl over-expressing cells...
5.
Gutekunst M, Oren M, Weilbacher A, Dengler M, Markwardt C, Thomale J, et al.
PLoS One
. 2011 May;
6(4):e19198.
PMID: 21532991
Consistent with the excellent clinical results in testicular germ cell tumors (TGCT), most cell lines derived from this cancer show an exquisite sensitivity to Cisplatin. It is well accepted that...
6.
Skorta I, Oren M, Markwardt C, Gutekunst M, Aulitzky W, van der Kuip H
Cancer Res
. 2009 Nov;
69(24):9337-45.
PMID: 19934315
Imatinib is highly effective in inducing remission in chronic myelogenous leukemia (CML). However, complete eradication of the malignant clone by imatinib is rare. We investigated the efficacy of combining imatinib...