Matthew T J Halma
Overview
Explore the profile of Matthew T J Halma including associated specialties, affiliations and a list of published articles.
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12
Citations
87
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Recent Articles
1.
Halma M, Kumar S, van Eck J, Abeln S, Gates A, Wuite G
Biophys J
. 2025 Mar;
PMID: 40083158
The single-molecule biophysics community has delivered significant impacts to our understanding of fundamental biological processes, yet the field is also siloed and has fragmented data structures which impede data sharing...
2.
Xu L, Halma M, Wuite G
Nat Commun
. 2024 Jun;
15(1):5328.
PMID: 38909023
Despite extensive studies on DNA replication, the exchange mechanisms of DNA polymerase during replication remain unclear. Existing models propose that this exchange is facilitated by protein partners like helicase. Here...
3.
Halma M, Xu L
Biophys Rep
. 2024 May;
10(1):48-56.
PMID: 38737478
Optical tweezers have elucidated numerous biological processes, particularly by enabling the precise manipulation and measurement of tension. One question concerns the biological relevance of these experiments and the generalizability of...
4.
Halma M, Tuszynski J, Marik P
Nutrients
. 2023 Oct;
15(19).
PMID: 37836529
Cancer is amenable to low-cost treatments, given that it has a significant metabolic component, which can be affected through diet and lifestyle change at minimal cost. The Warburg hypothesis states...
5.
Lech J, Halma M, Obajuluwa A, Baker M, Hamblin M
Ann Neurosci
. 2023 Sep;
30(2):133-142.
PMID: 37706102
Background: The relationship between the quality of the learning environment and student outcomes is receiving more serious attention from educational psychologists, neurologists, ophthalmologists, orthopedists, surgeons, oncologists, architects, ergonomists, nutritionists, and...
6.
Halma M, Plothe C, Marik P, Lawrie T
Microorganisms
. 2023 Jun;
11(5).
PMID: 37317282
In the wake of the COVID-19 crisis, a need has arisen to prevent and treat two related conditions, COVID-19 vaccine injury and long COVID-19, both of which can trace at...
7.
Xu L, Cabanas-Danes J, Halma M, Heller I, Stratmann S, van Oijen A, et al.
Nucleic Acids Res
. 2023 May;
51(13):6540-6553.
PMID: 37254785
Bacteriophage T7 single-stranded DNA-binding protein (gp2.5) binds to and protects transiently exposed regions of single-stranded DNA (ssDNA) while dynamically interacting with other proteins of the replication complex. We directly visualize...
8.
Xu L, Halma M, Wuite G
Int J Mol Sci
. 2023 Feb;
24(3).
PMID: 36769124
Single-stranded DNA-binding proteins (SSBs) play vital roles in DNA metabolism. Proteins of the SSB family exclusively and transiently bind to ssDNA, preventing the DNA double helix from re-annealing and maintaining...
9.
Halma M, Wever M, Abeln S, Roche D, Wuite G
Front Chem
. 2022 Dec;
10:1062352.
PMID: 36561139
The economical and societal impact of COVID-19 has made the development of vaccines and drugs to combat SARS-CoV-2 infection a priority. While the SARS-CoV-2 spike protein has been widely explored...
10.
Halma M, Tuszynski J, Wuite G
Drug Discov Today
. 2022 Nov;
28(1):103443.
PMID: 36396117
The time taken and the cost of producing novel therapeutic drugs presents a significant burden - a typical target-based drug discovery process involves computational screening of drug libraries, compound assays...