Matthew R Tiffany
Overview
Explore the profile of Matthew R Tiffany including associated specialties, affiliations and a list of published articles.
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6
Citations
346
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Recent Articles
1.
Pekrun K, de Alencastro G, Luo Q, Liu J, Kim Y, Nygaard S, et al.
JCI Insight
. 2019 Nov;
4(22).
PMID: 31723052
While gene transfer using recombinant adeno-associated viral (rAAV) vectors has shown success in some clinical trials, there remain many tissues that are not well transduced. Because of the recent success...
2.
Sockolosky J, Trotta E, Parisi G, Picton L, Su L, Le A, et al.
Science
. 2018 Mar;
359(6379):1037-1042.
PMID: 29496879
Interleukin-2 (IL-2) is a cytokine required for effector T cell expansion, survival, and function, especially for engineered T cells in adoptive cell immunotherapy, but its pleiotropy leads to simultaneous stimulation...
3.
Ho C, Chhabra A, Starkl P, Schnorr P, Wilmes S, Moraga I, et al.
Cell
. 2017 Mar;
168(6):1041-1052.e18.
PMID: 28283060
Most secreted growth factors and cytokines are functionally pleiotropic because their receptors are expressed on diverse cell types. While important for normal mammalian physiology, pleiotropy limits the efficacy of cytokines...
4.
Kohli A, Kivimae S, Tiffany M, Szoka F
J Control Release
. 2014 May;
191:105-14.
PMID: 24852095
Liposomes improve the pharmacokinetics and safety of rapidly cleared drugs, but have not yet improved the clinical efficacy compared to the non-encapsulated drug. This inability to improve efficacy may be...
5.
Walsh C, Nguyen J, Tiffany M, Szoka F
Bioconjug Chem
. 2012 Nov;
24(1):36-43.
PMID: 23176544
We report the synthesis and characterization of a series of ionizable lysine-based lipids (ILL), novel lipids containing a lysine headgroup linked to a long-chain dialkylamine through an amide linkage at...
6.
Sockolosky J, Tiffany M, Szoka F
Proc Natl Acad Sci U S A
. 2012 Sep;
109(40):16095-100.
PMID: 22991460
The importance of therapeutic recombinant proteins in medicine has led to a variety of tactics to increase their circulation time or to enable routes of administration other than injection. One...