Matthew P Hirakawa
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Explore the profile of Matthew P Hirakawa including associated specialties, affiliations and a list of published articles.
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21
Citations
915
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Recent Articles
1.
Hirakawa M, Rodriguez A, Tran-Gyamfi M, Light Y, Martinez S, Diamond-Pott H, et al.
J Fungi (Basel)
. 2023 Mar;
9(3).
PMID: 36983539
is a widespread white-rot basidiomycete fungus with significance in diverse biotechnological applications due to its ability to degrade aromatic compounds, xenobiotics, and lignin using an assortment of oxidative enzymes including...
2.
Hirakawa M, Tjahjono N, Light Y, Celebi A, Celebi N, Chintalapudi P, et al.
iScience
. 2022 Feb;
25(2):103759.
PMID: 35141503
Mesenchymal stromal cells (MSCs) have broad-ranging therapeutic properties, including the ability to inhibit bacterial growth and resolve infection. However, the genetic mechanisms regulating these antibacterial properties in MSCs are largely...
3.
Thomson G, Kakade P, Hirakawa M, Ene I, Bennett R
G3 (Bethesda)
. 2021 Apr;
11(7).
PMID: 33836061
The opportunistic fungal pathogen Candida albicans undergoes an unusual parasexual cycle wherein diploid cells mate to form tetraploid cells that can generate genetically diverse progeny via a nonmeiotic program of...
4.
Hirakawa M, Krishnakumar R, Timlin J, Carney J, Butler K
Biosci Rep
. 2020 Mar;
40(4).
PMID: 32207531
Genome editing technologies, particularly those based on zinc-finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and CRISPR (clustered regularly interspaced short palindromic repeat DNA sequences)/Cas9 are rapidly progressing into clinical...
5.
Anderson M, Thomson G, Hirakawa M, Bennett R
Nat Commun
. 2019 Sep;
10(1):4388.
PMID: 31558727
Meiosis is a conserved tenet of sexual reproduction in eukaryotes, yet this program is seemingly absent from many extant species. In the human fungal pathogen Candida albicans, mating of diploid...
6.
Liang S, Anderson M, Hirakawa M, Wang J, Frazer C, Alaalm L, et al.
Cell Host Microbe
. 2019 Mar;
25(3):418-431.e6.
PMID: 30824263
Candida albicans is a commensal fungus of human gastrointestinal and reproductive tracts, but also causes life-threatening systemic infections. The balance between colonization and pathogenesis is associated with phenotypic plasticity, with...
7.
Ene I, Farrer R, Hirakawa M, Agwamba K, Cuomo C, Bennett R
Proc Natl Acad Sci U S A
. 2018 Aug;
115(37):E8688-E8697.
PMID: 30150418
is a heterozygous diploid yeast that is a commensal of the human gastrointestinal tract and a prevalent opportunistic pathogen. Here, whole-genome sequencing was performed on multiple isolates passaged both in...
8.
Hirakawa M, Chyou D, Huang D, Slan A, Bennett R
Genetics
. 2017 Sep;
207(3):1195-1211.
PMID: 28912344
is a diploid fungus that is a frequent cause of mucosal and systemic infections in humans. This species exhibits an unusual parasexual cycle in which mating produces tetraploid cells that...
9.
Regan H, Scaduto C, Hirakawa M, Gunsalus K, Correia-Mesquita T, Sun Y, et al.
Mol Microbiol
. 2017 Jun;
105(5):810-824.
PMID: 28657681
Transcriptional regulation involves both positive and negative regulatory elements. The Dig1 negative regulators are part of a fungal-specific module that includes a transcription factor (a Ste12 family member) and a...
10.
Sun Y, Gadoury C, Hirakawa M, Bennett R, Harcus D, Marcil A, et al.
mBio
. 2016 Apr;
7(2):e00465-16.
PMID: 27118591
Unlabelled: It has been proposed that the ancestral fungus was mating competent and homothallic. However, many mating-competent fungi were initially classified as asexual because their mating capacity was hidden behind...