Matthew Lambert
Overview
Explore the profile of Matthew Lambert including associated specialties, affiliations and a list of published articles.
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25
Citations
519
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Recent Articles
1.
Weir-McCall J, Fitton C, Gandy S, Lambert M, Littleford R, Houston J, et al.
Radiology
. 2024 Nov;
313(2):e232997.
PMID: 39499172
Background Left ventricular mass (LVM) is an established marker of cardiovascular risk; however, long-term follow-up studies in individuals with low to intermediate risk are lacking. Purpose To assess the sex-specific...
2.
Shafer M, Bobholz M, Vuyk W, Gregory D, Roguet A, Haddock Soto L, et al.
Lancet Microbe
. 2024 Mar;
5(4):e335-e344.
PMID: 38484748
Background: The origin of novel SARS-CoV-2 spike sequences found in wastewater, without corresponding detection in clinical specimens, remains unclear. We sought to determine the origin of one such cryptic wastewater...
3.
Makowski E, Chen H, Lambert M, Bennett E, Eschmann N, Zhang Y, et al.
MAbs
. 2022 Nov;
14(1):2146629.
PMID: 36433737
Self-association governs the viscosity and solubility of therapeutic antibodies in high-concentration formulations used for subcutaneous delivery, yet it is difficult to reliably identify candidates with low self-association during antibody discovery...
4.
Brinth A, Svenson K, Mosyak L, Cunningham O, Hickling T, Lambert M
Sci Rep
. 2022 May;
12(1):8699.
PMID: 35610505
Administration of therapeutic antibodies can elicit adverse immune responses in patients through the generation of anti-drug antibodies that, in turn, reduce the efficacy of the therapeutic. Removal of foreign amino...
5.
Breen D, Jagarlapudi S, Patel A, Zou C, Joaquim S, Li X, et al.
iScience
. 2021 Jun;
24(6):102554.
PMID: 34189431
Growth differentiation factor 15 (GDF15) causes anorexia and weight loss in animal models, and higher circulating levels are associated with cachexia and reduced survival in cancer and other chronic diseases...
6.
Campbell S, DeBartolo J, Apgar J, Mosyak L, McManus V, Beyer S, et al.
MAbs
. 2021 Feb;
13(1):1883239.
PMID: 33557673
Despite substantial technological advances in antibody library and display platform development, the number of approved biotherapeutics from displayed libraries remains limited. , 20-50% of peripheral B cells undergo a process...
7.
Breen D, Kim H, Bennett D, Calle R, Collins S, Esquejo R, et al.
Cell Metab
. 2020 Nov;
32(6):938-950.e6.
PMID: 33207247
Platinum-based cancer therapy is restricted by dose-limiting side effects and is associated with elevation of growth differentiation factor 15 (GDF-15). But whether this elevation contributes to such side effects has...
8.
Fazavana J, Brophy T, Chion A, Cooke N, Terraube V, Cohen J, et al.
J Thromb Haemost
. 2020 Feb;
18(6):1278-1290.
PMID: 32108991
Background: Previous studies have demonstrated that the A1A2A3 domains of von Willebrand factor (VWF) play a key role in regulating macrophage-mediated clearance in vivo. In particular, the A1-domain has been...
9.
Arezes J, Foy N, McHugh K, Quinkert D, Benard S, Sawant A, et al.
Blood
. 2020 Jan;
135(8):547-557.
PMID: 31899794
Erythroferrone (ERFE) is produced by erythroblasts in response to erythropoietin (EPO) and acts in the liver to prevent hepcidin stimulation by BMP6. Hepcidin suppression allows for the mobilization of iron...
10.
Root A, Cao W, Li B, LaPan P, Meade C, Sanford J, et al.
Antibodies (Basel)
. 2019 Sep;
5(1).
PMID: 31557987
Bispecific antibodies offer a promising approach for the treatment of cancer but can be challenging to engineer and manufacture. Here we report the development of PF-06671008, an extended-half-life dual-affinity re-targeting...