Matthew D Worssam
Overview
Explore the profile of Matthew D Worssam including associated specialties, affiliations and a list of published articles.
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7
Citations
41
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0
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Recent Articles
1.
Lambert J, Oc S, Worssam M, Haussler D, Solomon C, Figg N, et al.
Nat Cardiovasc Res
. 2024 Aug;
3(6):714-733.
PMID: 39215134
Aberrant vascular smooth muscle cell (VSMC) homeostasis and proliferation characterize vascular diseases causing heart attack and stroke. Here we elucidate molecular determinants governing VSMC proliferation by reconstructing gene regulatory networks...
2.
Weldy C, Li Q, Monteiro J, Guo H, Galls D, Gu W, et al.
bioRxiv
. 2024 Jul;
PMID: 39026721
One Sentence Summary: Smooth muscle expression of RNA editing enzyme ADAR1 regulates activation of double strand RNA sensor MDA5 in novel mechanism of atherosclerosis.
3.
Quertermous T, Li D, Weldy C, Ramste M, Sharma D, Monteiro J, et al.
Arterioscler Thromb Vasc Biol
. 2024 Jan;
44(2):323-327.
PMID: 38266112
Objective: The goal of this review is to discuss the implementation of genome-wide association studies to identify causal mechanisms of vascular disease risk. Approach And Results: The history of genome-wide...
4.
Sharma D, Worssam M, Pedroza A, Dalal A, Alemany H, Kim H, et al.
Arterioscler Thromb Vasc Biol
. 2023 Dec;
44(2):391-408.
PMID: 38152886
Background: The application of single-cell transcriptomic (single-cell RNA sequencing) analysis to the study of atherosclerosis has provided unique insights into the molecular and genetic mechanisms that mediate disease risk and...
5.
Worssam M, Jorgensen H
Biochem Soc Trans
. 2021 Sep;
49(5):2101-2111.
PMID: 34495326
In contrast with the heart, the adult mammalian vasculature retains significant remodelling capacity, dysregulation of which is implicated in disease development. In particular, vascular smooth muscle cells (VSMCs) play major...
6.
Harman J, Dobnikar L, Chappell J, Stokell B, Dalby A, Foote K, et al.
Arterioscler Thromb Vasc Biol
. 2019 Aug;
39(11):2289-2302.
PMID: 31434493
Objective: Vascular inflammation underlies cardiovascular disease. Vascular smooth muscle cells (VSMCs) upregulate selective genes, including MMPs (matrix metalloproteinases) and proinflammatory cytokines upon local inflammation, which directly contribute to vascular disease...