Matthew Cox
Overview
Explore the profile of Matthew Cox including associated specialties, affiliations and a list of published articles.
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Articles
36
Citations
311
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Recent Articles
1.
Poudel Y, Lo J, Norris D, Cox M, He L, Johnson W, et al.
ACS Med Chem Lett
. 2025 Jan;
16(1):80-88.
PMID: 39811121
Dual activation of the TLR7 and TLR8 pathways leads to the production of type I interferon and proinflammatory cytokines, resulting in efficient antigen presentation by dendritic cells to promote T-cell...
2.
Mir D, Cox M, Horrocks J, Ma Z, Rogers A
J Clin Med Sci
. 2024 Sep;
8(2).
PMID: 39323482
Dietary Restriction (DR) mitigates loss of proteostasis associated with aging that underlies neurodegenerative conditions including Alzheimer's disease and related dementias. Previously, we observed increased translational efficiency of certain FMRFamide-Like neuro-Peptide...
3.
Snow S, Mir D, Ma Z, Horrocks J, Cox M, Ruzga M, et al.
Front Biosci (Landmark Ed)
. 2024 Jul;
29(7):264.
PMID: 39082355
Background: The ability to maintain muscle function decreases with age and loss of proteostatic function. Diet, drugs, and genetic interventions that restrict nutrients or nutrient signaling help preserve long-term muscle...
4.
Snow S, Mir D, Ma Z, Horrocks J, Cox M, Ruzga M, et al.
bioRxiv
. 2024 Apr;
PMID: 38559178
Background: The ability to maintain muscle function decreases with age and loss of proteostatic function. Diet, drugs, and genetic interventions that restrict nutrients or nutrient signaling help preserve long-term muscle...
5.
Mir D, Cox M, Horrocks J, Ma Z, Rogers A
bioRxiv
. 2024 Feb;
PMID: 38370756
Dietary restriction (DR) mitigates loss of proteostasis associated with aging that underlies neurodegenerative conditions including Alzheimer's disease and related dementias. Previously, we observed increased translational efficiency of certain FMRFamide-like neuropeptide...
6.
He L, Zhang M, Cox M, Zhang Q, Donnell A, Zhang Y, et al.
ACS Med Chem Lett
. 2024 Feb;
15(2):189-196.
PMID: 38352849
Small molecule toll-like receptor (TLR) 7 agonists have gathered considerable interest as promising therapeutic agents for applications in cancer immunotherapy. Herein, we describe the development and optimization of a series...
7.
Poudel Y, He L, Cox M, Zhang Q, Johnson W, Cong Q, et al.
ACS Med Chem Lett
. 2024 Feb;
15(2):181-188.
PMID: 38352830
We have designed and developed novel and selective TLR7 agonists that exhibited potent receptor activity in a cell-based reporter assay. , these agonists significantly induced secretion of cytokines IL-6, IL-1β,...
8.
Ma Z, Horrocks J, Mir D, Cox M, Ruzga M, Rollins J, et al.
Front Cell Dev Biol
. 2024 Jan;
11:1263344.
PMID: 38161330
The highly conserved integrated stress response (ISR) reduces and redirects mRNA translation in response to certain forms of stress and nutrient limitation. It is activated when kinases phosphorylate a key...
9.
Luo H, Li Y, Robbins D, Wang S, Xi G, Cox M, et al.
Biotechnol Prog
. 2020 Dec;
37(3):e3119.
PMID: 33373106
Process-related impurities (PRIs) derived from manufacturing process should be minimized in final drug product. ICH Q3A provides a regulatory road map for PRIs but excludes biologic drugs like monoclonal antibodies...
10.
Knights H, Mayor N, Millar K, Cox M, Bunova E, Hughes M, et al.
Clin Med (Lond)
. 2020 Jul;
20(5):e148-e153.
PMID: 32709637
Background: This retrospective cohort study aims to define the clinical findings and outcomes of every patient admitted to a district general hospital in Surrey with COVID-19 in March 2020, providing...