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Matthew C Hearing

Explore the profile of Matthew C Hearing including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 17
Citations 361
Followers 0
Related Specialties
Neurology
Psychiatry
Science
Top 10 Co-Authors
Eden M Anderson
Kevin Wickman
Mark J Thomas
Anna E Ingebretson
Annabel Engelhardt
Stephanie R Ebner
Erin B Larson
Skyler Demis
Rachel A Fischer
Devan Gomez
Published In
J Neurosci
Neuropsychopharmacology
Proc Natl Acad Sci U S A
Neuroreport
Rev Neurosci
Affiliations
Soon will be listed here.
Recent Articles
1.
Adolescent morphine exposure impairs cognitive flexibility in female but not male mice
Wakhlu A, Engelhardt A, Anderson E, Grafelman E, Ouimet A, Hearing M
bioRxiv . 2023 Apr; PMID: 37090510
Use of prescription opioids continues to rise, especially in adolescent individuals. As adolescence is a critical development window for higher order cognitive functions, thus opioid exposure during this period may...
2.
Complexes of Ghrelin GHS-R1a, GHS-R1b, and Dopamine D Receptors Localized in the Ventral Tegmental Area as Main Mediators of the Dopaminergic Effects of Ghrelin
Navarro G, Rea W, Quiroz C, Moreno E, Gomez D, Wenthur C, et al.
J Neurosci . 2021 Dec; 42(6):940-953. PMID: 34876469
Ghrelin receptor, also known as growth hormone secretagogue receptor (GHS-R1a), is coexpressed with its truncated isoform GHS-R1b, which does not bind ghrelin or signal, but oligomerizes with GHS-R1a, exerting a...
3.
Infralimbic cortex pyramidal neuron GIRK signaling contributes to regulation of cognitive flexibility but not affect-related behavior in male mice
Anderson E, Demis S, Wrucke B, Engelhardt A, Hearing M
Physiol Behav . 2021 Sep; 242:113597. PMID: 34536435
Dysfunction of the infralimbic cortical (ILC) region of the medial prefrontal cortex (mPFC) is thought to be an underlying factor in both affect- and cognition-related behavioral deficits that co-occur across...
4.
Suppression of pyramidal neuron G protein-gated inwardly rectifying K+ channel signaling impairs prelimbic cortical function and underlies stress-induced deficits in cognitive flexibility in male, but not female, mice
Anderson E, Loke S, Wrucke B, Engelhardt A, Demis S, OReilly K, et al.
Neuropsychopharmacology . 2021 Jun; 46(12):2158-2169. PMID: 34158613
Imbalance in prefrontal cortical (PFC) pyramidal neuron excitation:inhibition is thought to underlie symptomologies shared across stress-related disorders and neuropsychiatric disease, including dysregulation of emotion and cognitive function. G protein-gated inwardly...
5.
Remifentanil self-administration in mice promotes sex-specific prefrontal cortex dysfunction underlying deficits in cognitive flexibility
Anderson E, Engelhardt A, Demis S, Porath E, Hearing M
Neuropsychopharmacology . 2021 May; 46(10):1734-1745. PMID: 34012018
Opioid-based drugs are frequently used for pain management in both males and females despite the known risk of prefrontal cortex dysfunction and cognitive impairments. Although poorly understood, loss of cognitive...
6.
Estradiol Regulation of the Prelimbic Cortex and the Reinstatement of Cocaine Seeking in Female Rats
Doncheck E, Anderson E, Konrath C, Liddiard G, DeBaker M, Urbanik L, et al.
J Neurosci . 2021 Apr; 41(24):5303-5314. PMID: 33879537
Relapse susceptibility in women with substance use disorders (SUDs) has been linked to the estrogen, 17β-estradiol (E2). Our previous findings in female rats suggest that the influence of E2 on...
7.
Cell-type and region-specific nucleus accumbens AMPAR plasticity associated with morphine reward, reinstatement, and spontaneous withdrawal
Madayag A, Gomez D, Anderson E, Ingebretson A, Thomas M, Hearing M
Brain Struct Funct . 2019 Jun; 224(7):2311-2324. PMID: 31201496
Despite evidence that morphine-related pathologies reflect adaptations in NAc glutamate signaling, substantial gaps in basic information remain. The current study examines the impact of non-contingent acute, repeated, and withdrawal-inducing morphine...
8.
Synaptic Depotentiation and mGluR5 Activity in the Nucleus Accumbens Drive Cocaine-Primed Reinstatement of Place Preference
Benneyworth M, Hearing M, Asp A, Madayag A, Ingebretson A, Schmidt C, et al.
J Neurosci . 2019 Apr; 39(24):4785-4796. PMID: 30948476
Understanding the neurobiological processes that incite drug craving and drive relapse has the potential to help target efforts to treat addiction. The NAc serves as a critical substrate for reward...
9.
Extinction and Reinstatement of Cocaine-seeking in Self-administering Mice is Associated with Bidirectional AMPAR-mediated Plasticity in the Nucleus Accumbens Shell
Ebner S, Larson E, Hearing M, Ingebretson A, Thomas M
Neuroscience . 2018 Jun; 384:340-349. PMID: 29885524
Experience-dependent synaptic plasticity is an important component of both learning and motivational disturbances found in addicted individuals. Here, we investigated the role of cocaine experience-dependent plasticity at excitatory synapses in...
10.
Endogenous dopamine and endocannabinoid signaling mediate cocaine-induced reversal of AMPAR synaptic potentiation in the nucleus accumbens shell
Ingebretson A, Hearing M, Huffington E, Thomas M
Neuropharmacology . 2017 Dec; 131:154-165. PMID: 29225042
Repeated exposure to drugs of abuse alters the structure and function of neural circuits mediating reward, generating maladaptive plasticity in circuits critical for motivated behavior. Within meso-corticolimbic dopamine circuitry, repeated...