Matthew B Smith
Overview
Explore the profile of Matthew B Smith including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
455
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0
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Recent Articles
1.
Lefferts J, Kroes S, Smith M, Niemoller P, Nieuwenhuijze N, Sonneveld van Kooten H, et al.
Commun Biol
. 2024 Mar;
7(1):319.
PMID: 38480810
Epithelial ion and fluid transport studies in patient-derived organoids (PDOs) are increasingly being used for preclinical studies, drug development and precision medicine applications. Epithelial fluid transport properties in PDOs can...
2.
Smith M, Sparks H, Almagro J, Chaigne A, Behrens A, Dunsby C, et al.
Biophys J
. 2023 Apr;
122(9):1586-1599.
PMID: 37002604
Segmenting cells within cellular aggregates in 3D is a growing challenge in cell biology due to improvements in capacity and accuracy of microscopy techniques. Here, we describe a pipeline to...
3.
Gutteridge C, Sadowski B, Hughes S, Friedlander J, Gaidry A, Baxter M, et al.
Med Chem
. 2022 Aug;
19(5):478-484.
PMID: 35993460
Objective: A series of novel, substituted tetracyclic benzothiazepines were designed and prepared in an effort to optimize the potency of this chemical class against drug-resistant strains of the malaria parasite....
4.
Kelkar M, Bohec P, Smith M, Sreenivasan V, Lisica A, Valon L, et al.
Proc Natl Acad Sci U S A
. 2022 Jun;
119(26):e2121868119.
PMID: 35727980
Proper orientation of the mitotic spindle plays a crucial role in embryos, during tissue development, and in adults, where it functions to dissipate mechanical stress to maintain tissue integrity and...
5.
Davis J, Ainslie A, Williamson J, Ferreira A, Torres-Sanchez A, Hoppe A, et al.
Curr Biol
. 2022 Feb;
32(6):1285-1300.e4.
PMID: 35167804
During development, multicellular organisms undergo stereotypical patterns of tissue growth in space and time. How developmental growth is orchestrated remains unclear, largely due to the difficulty of observing and quantitating...
6.
Chaigne A, Smith M, Lopez Cavestany R, Hannezo E, Chalut K, Paluch E
J Cell Sci
. 2021 Jul;
134(14).
PMID: 34323278
Proper control of division orientation and symmetry, largely determined by spindle positioning, is essential to development and homeostasis. Spindle positioning has been extensively studied in cells dividing in two-dimensional (2D)...
7.
Cao L, Yonis A, Vaghela M, Barriga E, Chugh P, Smith M, et al.
Nat Cell Biol
. 2020 Jun;
22(7):803-814.
PMID: 32572169
Cell shape is controlled by the submembranous cortex, an actomyosin network mainly generated by two actin nucleators: the Arp2/3 complex and the formin mDia1. Changes in relative nucleator activity may...
8.
Chugh P, Clark A, Smith M, Cassani D, Dierkes K, Ragab A, et al.
Nat Cell Biol
. 2017 May;
19(6):689-697.
PMID: 28530659
Animal cell shape is largely determined by the cortex, a thin actin network underlying the plasma membrane in which myosin-driven stresses generate contractile tension. Tension gradients result in local contractions...
9.
10.
Yamashiro S, Mizuno H, Smith M, Ryan G, Kiuchi T, Vavylonis D, et al.
Mol Biol Cell
. 2014 Feb;
25(7):1010-24.
PMID: 24501425
Speckle microscopy directly visualizes the retrograde actin flow, which is believed to promote cell-edge protrusion when linked to focal adhesions (FAs). However, it has been argued that, due to rapid...