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Matteo Pappalardo

Explore the profile of Matteo Pappalardo including associated specialties, affiliations and a list of published articles. Areas
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Articles 27
Citations 153
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Recent Articles
21.
Federico C, Motta S, Palmieri C, Pappalardo M, Librando V, Saccone S
Mutat Res . 2011 Jan; 721(1):89-94. PMID: 21238602
The intensive use of herbicides over the last few decades has caused a general increase of environmental pollution. It is thus very important to evaluate the possible genotoxic properties of...
22.
Milardi D, Sciacca M, Pappalardo M, Grasso D, La Rosa C
Eur Biophys J . 2010 Sep; 40(1):1-12. PMID: 20809197
Human islet amyloid polypeptide (hIAPP) is known to misfold and aggregate into amyloid deposits that may be found in pancreatic tissues of patients affected by type 2 diabetes. Recent studies...
23.
Milardi D, Pappalardo M, Grasso D, La Rosa C
Mol Biosyst . 2010 May; 6(6):1032-9. PMID: 20485746
Although the molecular determinants of Familial Amyotrophic Lateral Sclerosis (FALS) are still largely unknown, previous studies have demonstrated that aggregation of Cu, Zn superoxide dismutase (SOD1) mutants may play a...
24.
Sciacca M, Pappalardo M, Milardi D, Grasso D, La Rosa C
Arch Biochem Biophys . 2008 Jul; 477(2):291-8. PMID: 18621014
The role played by Ca(2+) ions in the interaction of the human islet amyloid polypeptide (hIAPP) with model membranes has been investigated by differential scanning calorimetry (DSC) and circular dichroism...
25.
Manetto G, Grasso D, Milardi D, Pappalardo M, Guzzi R, Sportelli L, et al.
Chembiochem . 2007 Sep; 8(16):1941-9. PMID: 17868155
The role played by the alpha-helix in determining the structure, the stability and the unfolding mechanism of azurin was addressed by studying a helix-depleted azurin variant produced by site-directed mutagenesis....
26.
La Rosa C, Milardi D, Amato E, Pappalardo M, Grasso D
Arch Biochem Biophys . 2005 Feb; 435(1):182-9. PMID: 15680920
Experimental and computational studies suggest that few general principles govern protein/protein interactions and aggregation. The knowledge of these rules may be exploited to design peptides that are able to interfere...
27.
Pappalardo M, Milardi D, Grasso D, La Rosa C
J Comput Chem . 2003 Apr; 24(6):779-85. PMID: 12666170
Free energy perturbation/molecular dynamics simulations have been carried out on copper/azurin systems calculating the binding affinities of copper (II) ion to azurin either in the native or in the unfolded...