Matteo Pappalardo
Overview
Explore the profile of Matteo Pappalardo including associated specialties, affiliations and a list of published articles.
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Articles
27
Citations
153
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Recent Articles
1.
Pappalardo M, Sipala F, Nicolosi M, Guccione S, Ronsisvalle S
Molecules
. 2024 Nov;
29(22).
PMID: 39598735
In recent years, the advent of computational techniques to predict the potential activity of a drug interacting with a receptor or to predict the structure of unidentified proteins with aberrant...
2.
Ma O, Ronsisvalle S, Basile L, Xiang A, Tomasella C, Sipala F, et al.
Biomed Pharmacother
. 2022 Dec;
158:114141.
PMID: 36542987
Diabetic neuropathy (DN) is a long-term complication of diabetes mellitus, affecting different periphery nerve systems including sensory and motor neurons. Hyperglycemia is the major cause of DN with symptoms such...
3.
Ramsay R, Basile L, Maniquet A, Hagenow S, Pappalardo M, Saija M, et al.
Molecules
. 2020 Dec;
25(24).
PMID: 33322203
The irreversible inhibitors of monoamine oxidases (MAO) slow neurotransmitter metabolism in depression and neurodegenerative diseases. After oxidation by MAO, hydrazines, cyclopropylamines and propargylamines form a covalent adduct with the flavin...
4.
Ronsisvalle S, Panarello F, Spadaro A, Franchini S, Pappalardo M, Guccione S, et al.
Future Med Chem
. 2020 Sep;
12(22):2001-2018.
PMID: 32972243
Central and peripheral analgesia without adverse effects relies on the identification of μ-opioid agonists that are able to activate 'basal' antinociceptive pathways. Recently developed μ-selective benzomorphan agonists that are not...
5.
Tomasella C, Floris M, Guccione S, Pappalardo M, Basile L
Mol Inform
. 2020 Sep;
40(3):e2000087.
PMID: 32954671
Endogenous peptides as part of physiological processes are targets of interest when it comes to finding desirable therapeutics which are able to modulate molecular interactions. The major limits presented by...
6.
Spadaro A, Basile L, Pappalardo M, Bonaccorso C, Rao M, Ronsisvalle S, et al.
J Chem Inf Model
. 2020 Aug;
60(10):5162-5171.
PMID: 32818373
Functional antitumor vaccine constructs are the basis for active tumor immunotherapy, which is useful in the treatment of many types of cancers. MUC1 is one key glycoprotein for targeting and...
7.
Pappalardo M, Rayan M, Abu-Lafi S, Leonardi M, Milardi D, Guccione S, et al.
Mol Inform
. 2017 Apr;
36(8).
PMID: 28375549
Modeling G-Protein Coupled Receptors (GPCRs) is an emergent field of research, since utility of high-quality models in receptor structure-based strategies might facilitate the discovery of interesting drug candidates. The findings...
8.
Shahaf N, Pappalardo M, Basile L, Guccione S, Rayan A
Mol Inform
. 2016 Aug;
35(8-9):414-23.
PMID: 27546045
G protein-coupled receptors (GPCRs) are a super-family of membrane proteins that attract great pharmaceutical interest due to their involvement in almost every physiological activity, including extracellular stimuli, neurotransmission, and hormone...
9.
Federico C, Palmieri C, Pappalardo A, Ferrito V, Pappalardo M, Librando V, et al.
Environ Sci Pollut Res Int
. 2016 May;
23(17):17018-25.
PMID: 27206752
Agricultural practices are usually supported by several chemical substances, such as herbicides. Linuron and chlorbromuron are phenylurea herbicides largely used to protect crops from weeds, blocking photosynthesis by inhibition of...
10.
Impellizzeri A, Pappalardo M, Basile L, Manfra O, Andressen K, Krobert K, et al.
Front Behav Neurosci
. 2015 May;
9:92.
PMID: 26005408
The human 5-HT7 receptor is expressed in both the central nervous system and peripheral tissues and is a potential drug target in behavioral and psychiatric disorders. We examined molecular determinants...