Matt Mealiffe
Overview
Explore the profile of Matt Mealiffe including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
3
Citations
246
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0
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Recent Articles
1.
Insogna K, Rauch F, Kamenicky P, Ito N, Kubota T, Nakamura A, et al.
J Bone Miner Res
. 2019 Aug;
34(12):2183-2191.
PMID: 31369697
In adults with X-linked hypophosphatemia (XLH), excess FGF23 impairs renal phosphate reabsorption and suppresses production of 1,25-dihydroxyvitamin D, resulting in chronic hypophosphatemia and persistent osteomalacia. Osteomalacia is associated with poor...
2.
Portale A, Carpenter T, Brandi M, Briot K, Cheong H, Cohen-Solal M, et al.
Calcif Tissue Int
. 2019 Jun;
105(3):271-284.
PMID: 31165191
Burosumab, a fully human monoclonal antibody to FGF23, is the only approved treatment for X-linked hypophosphatemia (XLH), a rare genetic disorder characterized by renal phosphate wasting and substantial cumulative musculoskeletal...
3.
Insogna K, Briot K, Imel E, Kamenicky P, Ruppe M, Portale A, et al.
J Bone Miner Res
. 2018 Jun;
33(8):1383-1393.
PMID: 29947083
In X-linked hypophosphatemia (XLH), inherited loss-of-function mutations in the PHEX gene cause excess circulating levels of fibroblast growth factor 23 (FGF23), leading to lifelong renal phosphate wasting and hypophosphatemia. Adults...