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Mathieu Fieldes

Explore the profile of Mathieu Fieldes including associated specialties, affiliations and a list of published articles. Areas
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Articles 11
Citations 80
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Recent Articles
1.
Ahmed E, Fieldes M, Bourguignon C, Mianne J, Petit A, Amel N, et al.
Stem Cell Res . 2024 May; 77:103437. PMID: 38723411
Human pluripotent stem cells (hiPSC) represent a unique opportunity to model lung development and chronic bronchial diseases. We generated a hiPSC line from a highly characterized healthy heavy smoker male...
2.
Ahmed E, Fieldes M, Bourguignon C, Mianne J, Petit A, Jory M, et al.
Cells . 2022 Aug; 11(15). PMID: 35954266
Background: Chronic Obstructive Pulmonary Disease (COPD), a major cause of mortality and disability, is a complex disease with heterogeneous and ill-understood biological mechanisms. Human induced pluripotent stem cells (hiPSCs) are...
3.
Mianne J, Nasri A, Van C, Bourguignon C, Fieldes M, Ahmed E, et al.
BMC Biol . 2022 Jan; 20(1):8. PMID: 34996449
Background: The application of CRISPR/Cas9 technology in human induced pluripotent stem cells (hiPSC) holds tremendous potential for basic research and cell-based gene therapy. However, the fulfillment of these promises relies...
4.
Ahmed E, Fieldes M, Mianne J, Bourguignon C, Nasri A, Vachier I, et al.
Stem Cell Res . 2021 Oct; 56:102550. PMID: 34624616
Evidence highlights the concept of multiple trajectories leading to COPD. Early-life events (i.e., in utero lung development) may influence the maximally attained lung function and increase the risk to develop...
5.
Fieldes M, Bourguignon C, Assou S, Nasri A, Fort A, Vachier I, et al.
ERJ Open Res . 2021 Apr; 7(2). PMID: 33855061
Chronic obstructive pulmonary disease (COPD) is a common and preventable airway disease causing significant worldwide mortality and morbidity. Lifetime exposure to tobacco smoking and environmental particles are the two major...
6.
Fieldes M, Ahmed E, Bourguignon C, Mianne J, Martin M, Arnould C, et al.
Stem Cell Res . 2020 Oct; 49:102037. PMID: 33099111
Human pluripotent stem cells (hiPSC) are highly valuable tools to model lung development and chronic bronchial diseases. We generated a hiPSC line from a highly characterized 40-year-old healthy male nonsmoking...
7.
Mianne J, Bourguignon C, Van C, Fieldes M, Nasri A, Assou S, et al.
Cells . 2020 May; 9(5). PMID: 32466123
Recent advances in genome engineering based on the CRISPR/Cas9 technology have revolutionized our ability to manipulate genomic DNA. Its use in human pluripotent stem cells (hPSCs) has allowed a wide...
8.
Bourguignon C, Vernisse C, Mianne J, Fieldes M, Ahmed E, Petit A, et al.
Med Sci (Paris) . 2020 May; 36(4):382-388. PMID: 32356715
As burden of chronic respiratory diseases is constantly increasing, improving in vitro lung models is essential in order to reproduce as closely as possible the complex pulmonary architecture, responsible for...
9.
Assou S, Girault N, Plinet M, Bouckenheimer J, Sansac C, Combe M, et al.
Stem Cell Reports . 2020 Jan; 14(1):1-8. PMID: 31902703
Genomic integrity of human pluripotent stem cells (hPSCs) is essential for research and clinical applications. However, genetic abnormalities can accumulate during hPSC generation and routine culture and following gene editing....
10.
Ahmed E, Sansac C, Fieldes M, Bergougnoux A, Bourguignon C, Mianne J, et al.
Stem Cell Res . 2018 Oct; 33:15-19. PMID: 30296669
Primary Ciliary Dyskinesia (PCD) is a rare heterogeneous genetic disorder affecting motile cilia structure and function leading to lung disease. We generated induced pluripotent stem cells (iPSCs) from dermal fibroblasts...