Mathew A Coban
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Explore the profile of Mathew A Coban including associated specialties, affiliations and a list of published articles.
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7
Citations
36
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Recent Articles
1.
Shoari A, Ashja Ardalan A, Dimesa A, Coban M
Biomolecules
. 2025 Jan;
15(1).
PMID: 39858430
Colorectal cancer (CRC) remains one of the most prevalent and lethal cancers worldwide, prompting ongoing research into innovative therapeutic strategies. This review aims to systematically evaluate the role of gelatinases,...
2.
Structural and Functional Characterization of the Most Frequent Pathogenic PRKN Substitution p.R275W
Bustillos B, Cocker L, Coban M, Weber C, Bredenberg J, Boneski P, et al.
Cells
. 2024 Sep;
13(18.
PMID: 39329724
Mutations in the and genes are the most frequent genetic cause of early-onset Parkinson disease. The pathogenic p.R275W substitution in PRKN is the most frequent substitution observed in patients, and...
3.
Shoari A, Khalili-Tanha G, Coban M, Radisky E
Front Mol Biosci
. 2023 Dec;
10:1321956.
PMID: 38074088
The study of protein-protein interactions (PPIs) and the engineering of protein-based inhibitors often employ two distinct strategies. One approach leverages the power of combinatorial libraries, displaying large ensembles of mutant...
4.
Chaudhri E, Abbott J, Islam N, Weber C, Coban M, Bilgili A, et al.
Genes (Basel)
. 2023 Oct;
14(10).
PMID: 37895204
(1) Background: Mutations in , a transcriptional regulator of immunomodulating proteins, are a known cause of inborn errors of immunity. Our proband is a 22-year-old male with a diagnosis of...
5.
Fiesel F, Fricova D, Hayes C, Coban M, Hudec R, Bredenberg J, et al.
Autophagy
. 2022 Dec;
19(6):1711-1732.
PMID: 36469690
The ubiquitin (Ub) kinase-ligase pair PINK1-PRKN mediates the degradation of damaged mitochondria by macroautophagy/autophagy (mitophagy). PINK1 surveils mitochondria and upon stress accumulates on the mitochondrial surface where it phosphorylates serine...
6.
Coban M, Morrison J, Maharjan S, Hernandez Medina D, Li W, Zhang Y, et al.
Biomolecules
. 2021 Jun;
11(6).
PMID: 34071060
COVID-19 is a devastating respiratory and inflammatory illness caused by a new coronavirus that is rapidly spreading throughout the human population. Over the past 12 months, severe acute respiratory syndrome...
7.
Coban M, Blackburn P, Whitelaw M, van Haelst M, Atwal P, Caulfield T
Biomolecules
. 2020 Sep;
10(9).
PMID: 32932609
Single-minded homologue 1 (SIM1) is a transcription factor with numerous different physiological and developmental functions. SIM1 is a member of the class I basic helix-loop-helix-PER-ARNT-SIM (bHLH-PAS) transcription factor family, that...
8.
Coban M, Fraga S, Caulfield T
Curr Drug Discov Technol
. 2020 Mar;
18(3):365-378.
PMID: 32160847
Diseases are often caused by mutant proteins. Many drugs have limited effectiveness and/or toxic side effects because of a failure to selectively target the disease-causing mutant variant, rather than the...