Mateusz Jurga
Overview
Explore the profile of Mateusz Jurga including associated specialties, affiliations and a list of published articles.
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Articles
4
Citations
129
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0
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Recent Articles
1.
Ray S, Abugable A, Parker J, Liversidge K, Palminha N, Liao C, et al.
Nature
. 2022 Sep;
609(7929):1038-1047.
PMID: 36171374
Oxidative genome damage is an unavoidable consequence of cellular metabolism. It arises at gene regulatory elements by epigenetic demethylation during transcriptional activation. Here we show that promoters are protected from...
2.
Jurga M, Abugable A, Goldman A, El-Khamisy S
Nat Commun
. 2021 Sep;
12(1):5156.
PMID: 34526504
R-loops are by-products of transcription that must be tightly regulated to maintain genomic stability and gene expression. Here, we describe a mechanism for the regulation of the R-loop-specific helicase, senataxin...
3.
Boughey H, Jurga M, El-Khamisy S
Int J Mol Sci
. 2021 Jul;
22(11).
PMID: 34199458
As we age, our bodies accrue damage in the form of DNA mutations. These mutations lead to the generation of sub-optimal proteins, resulting in inadequate cellular homeostasis and senescence. The...
4.
Walker C, Herranz-Martin S, Karyka E, Liao C, Lewis K, Elsayed W, et al.
Nat Neurosci
. 2017 Jul;
20(9):1225-1235.
PMID: 28714954
Hexanucleotide repeat expansions represent the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia, though the mechanisms by which such expansions cause neurodegeneration are poorly understood. We...