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Mateusz Jedrzejewski

Explore the profile of Mateusz Jedrzejewski including associated specialties, affiliations and a list of published articles. Areas
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Articles 9
Citations 26
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Recent Articles
1.
Gackowski M, Jedrzejewski M, Medicharla S, Kondabala R, Madriwala B, Madra-Gackowska K, et al.
Pharmaceuticals (Basel) . 2024 Feb; 17(2). PMID: 38399378
Activated blood coagulation factor X (FXa) plays a critical initiation step of the blood-coagulation pathway and is considered a desirable target for anticoagulant drug development. It is reversibly inhibited by...
2.
Jedrzejewski M, Belza B, Lewandowska I, Sadlej M, Perlinska A, Augustyniak R, et al.
Comput Struct Biotechnol J . 2023 Aug; 21:3999-4008. PMID: 37649713
The Nep1 protein is essential for the formation of eukaryotic and archaeal small ribosomal subunits, and it catalyzes the site-directed SAM-dependent methylation of pseudouridine (Ψ) during pre-rRNA processing. It possesses...
3.
Jedrzejewski M, Szeleszczuk L, Pisklak D
Molecules . 2023 Aug; 28(15). PMID: 37570737
In this work, the catalytic mechanism of loganic acid methyltransferase was characterized at the molecular level. This enzyme is responsible for the biosynthesis of loganin, which is a precursor for...
4.
Ordon P, Komorowski L, Jedrzejewski M, Zaklika J
J Phys Chem A . 2020 Jan; 124(6):1076-1086. PMID: 31962040
The concept of a connectivity matrix, essential for the reaction fragility (RF) spectra technique for monitoring electron density evolution in a chemical reaction, has been supported with a novel formulation...
5.
Ordon P, Zaklika J, Jedrzejewski M, Komorowski L
J Phys Chem A . 2019 Dec; 124(2):328-338. PMID: 31815477
Computational scheme to obtain bond softening index λ, defined within the conceptual DFT, has been obtained with the use of the reaction fragility (RF) concept. Numerical results were obtained with...
6.
Ordon P, Komorowski L, Jedrzejewski M
J Chem Phys . 2017 Oct; 147(13):134109. PMID: 28987090
Theoretical justification has been provided to the method for monitoring the sequence of chemical bonds' rearrangement along a reaction path, by tracing the evolution of the diagonal elements of the...
7.
Komorowski L, Ordon P, Jedrzejewski M
Phys Chem Chem Phys . 2016 Nov; 18(48):32658-32663. PMID: 27892571
We report an original method that provides a new insight into the reaction mechanism by direct observation of bond breaking and formation. Variations of the diagonal elements of the Hessian...
8.
Jedrzejewski M, Ordon P, Komorowski L
J Phys Chem A . 2016 May; 120(21):3780-7. PMID: 27187521
Definite algorithms for calculation of the atomic contributions to the reaction force Fξ and the reaction force constant kξ (the first and the second derivatives of the energy over the...
9.
Jedrzejewski M, Ordon P, Komorowski L
J Mol Model . 2013 Mar; 19(10):4203-7. PMID: 23525962
The reaction force and the electronic flux, first proposed by Toro-Labbé et al. (J Phys Chem A 103:4398, 1999) have been expressed by the existing conceptual DFT apparatus. The critical...