Massimo Locati
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Explore the profile of Massimo Locati including associated specialties, affiliations and a list of published articles.
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166
Citations
20373
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Recent Articles
1.
Cafora M, Dobi D, William J, Forti F, Belleri L, Loberto N, et al.
J Cyst Fibros
. 2025 Mar;
PMID: 40055113
Cystic fibrosis is caused by biallelic mutations in the gene encoding the CFTR conductor channel. The recent approval of the Elexacaftor-Tezacaftor-Ivacaftor (ETI) therapy has marked a milestone in the management...
2.
Albano F, Mollica Poeta V, Zotti L, Castagna A, Felicetta A, Mesaglio A, et al.
J Immunother Cancer
. 2025 Jan;
13(1).
PMID: 39843164
Background: ACKR2 is an atypical chemokine receptor that plays a significant role in regulating inflammation by binding to inflammatory CC chemokines and facilitating their degradation. Previous findings suggest that the...
3.
Sfogliarini C, Tran L, Cesta C, Allegretti M, Locati M, Vegeto E
Biochem Pharmacol
. 2024 Sep;
229:116544.
PMID: 39293500
Beyond their clinical use as selective estrogen receptor modulators (SERMs), raloxifene and tamoxifen have attracted recent attention for their favorable activity against a broad range of dangerous human pathogens. While...
4.
Alarcan H, Bruno C, Emond P, Raoul C, Vourch P, Corcia P, et al.
Ann N Y Acad Sci
. 2024 May;
1536(1):82-91.
PMID: 38771698
Amyotrophic lateral sclerosis (ALS) is a devastating motor neuron disease. The immunosuppressive functions of regulatory T lymphocytes (Tregs) are impaired in ALS, and correlate to disease progression. The phase 2a...
5.
Rigamonti A, Viatore M, Polidori R, Rahal D, Erreni M, Fumagalli M, et al.
Cancer Res
. 2024 Feb;
84(7):1165-1177.
PMID: 38315789
Significance: Leveraging artificial intelligence-powered H&E analysis integrated with hi-plex imaging mass cytometry provides insights into the tumor ecosystem and can translate tumor features into classifiers to predict prognosis, genotype, and...
6.
Sfogliarini C, Pepe G, Cesta C, Allegretti M, Locati M, Vegeto E
Biomed Pharmacother
. 2023 Jul;
165:115008.
PMID: 37442065
Raloxifene belongs to the family of Selective Estrogen Receptor Modulators (SERMs), which are drugs widely prescribed for Estrogen Receptor alpha (ERα)-related pathologies. Recently, SERMs are being tested in repurposing strategies...
7.
Kumar R, Milanesi S, Szpakowska M, Dotta L, Silvestre D, Trotta A, et al.
JCI Insight
. 2023 Mar;
8(5).
PMID: 36883568
WHIM syndrome is an inherited immune disorder caused by an autosomal dominant heterozygous mutation in CXCR4. The disease is characterized by neutropenia/leukopenia (secondary to retention of mature neutrophils in bone...
8.
Carenza C, Franzese S, Castagna A, Terzoli S, Simonelli M, Persico P, et al.
Front Immunol
. 2023 Jan;
13:1074762.
PMID: 36703985
Introduction: Adult-type diffuse gliomas are malignant primary brain tumors characterized by very poor prognosis. Dendritic cells (DCs) are key in priming antitumor effector functions in cancer, but their role in...
9.
Vacchini A, Maffioli E, Silvestre D, Cancellieri C, Milanesi S, Nonnis S, et al.
Front Mol Biosci
. 2022 Dec;
9:1060555.
PMID: 36483536
ACKR2 is an atypical chemokine receptor which is structurally uncoupled from G proteins and is unable to activate signaling pathways used by conventional chemokine receptors to promote cell migration. Nonetheless,...
10.
Shojaee P, Mornata F, Deutsch A, Locati M, Hatzikirou H
Front Immunol
. 2022 Nov;
13:1050067.
PMID: 36439180
In this article, we review the role of mathematical modelling to elucidate the impact of tumor-associated macrophages (TAMs) in tumor progression and therapy design. We first outline the biology of...