Massimo Bortolotti
Overview
Explore the profile of Massimo Bortolotti including associated specialties, affiliations and a list of published articles.
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Articles
45
Citations
1067
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Recent Articles
1.
Bolognesi A, Bortolotti M, Battelli M, Polito L
Antioxidants (Basel)
. 2024 Feb;
13(2).
PMID: 38397809
Taking into account the patient's gender is the first step towards more precise and egalitarian medicine. The gender-related divergences observed in purine catabolism and their pathological consequences are good examples...
2.
Bortolotti M, Biscotti F, Zanello A, Polito L, Bolognesi A
Toxins (Basel)
. 2024 Jan;
16(1).
PMID: 38276525
Ribosome-inactivating proteins (RIPs) are plant toxins that were identified for their ability to irreversibly damage ribosomes, thereby causing arrest of protein synthesis and induction of cell death. The RIPs purified...
3.
Bortolotti M, Biscotti F, Zanello A, Bolognesi A, Polito L
Biomedicines
. 2023 May;
11(4).
PMID: 37189832
Saporin is a type 1 ribosome-inactivating protein widely used as toxic payload in the construction of targeted toxins, chimeric molecules formed by a toxic portion linked to a carrier moiety....
4.
Zanello A, Bortolotti M, Maiello S, Bolognesi A, Polito L
Front Pharmacol
. 2022 Sep;
13:972046.
PMID: 36052121
Immune checkpoint mechanisms are important molecular cell systems that maintain tolerance toward autoantigens in order to prevent immunity-mediated accidental damage. It is well known that cancer cells may exploit these...
5.
Polito L, Bortolotti M, Battelli M, Bolognesi A
Pharmacol Res
. 2022 Aug;
184:106407.
PMID: 35995347
The present review explores the role of xanthine oxidoreductase (XOR) in the development and progression of chronic kidney disease (CKD). Human XOR is a multi-level regulated enzyme, which has many...
6.
Bortolotti M, Polito L, Bolognesi A
Toxins (Basel)
. 2022 Jan;
14(1).
PMID: 35051040
The concept of "magic bullets", i [...].
7.
Maiello S, Iglesias R, Polito L, Citores L, Bortolotti M, Ferreras J, et al.
Toxins (Basel)
. 2021 Dec;
13(12).
PMID: 34941700
Kirkiin is a new type 2 ribosome-inactivating protein (RIP) purified from the caudex of with a cytotoxicity compared to that of stenodactylin. The high toxicity of RIPs from genus plants...
8.
Polito L, Bortolotti M, Battelli M, Bolognesi A
Redox Biol
. 2021 Nov;
48:102195.
PMID: 34844041
Cardiovascular diseases (CVD) are the leading cause of global mortality and their pathogenesis lies mainly in the atherosclerotic process. There are close connections linking oxidative stress and inflammation to endothelial...
9.
Polito L, Calafato G, Bortolotti M, Chiarelli Olivari C, Maiello S, Bolognesi A
Biomedicines
. 2021 Aug;
9(8).
PMID: 34440182
Sarcomas are one of the most difficult type of cancer to manage and treat because of their extremely heterogeneous molecular and morphological features. Despite the progress made over the years...
10.
Polito L, Bortolotti M, Iglesias R, Bolognesi A
Front Pharmacol
. 2021 May;
12:689924.
PMID: 33995114
No abstract available.