Masayoshi Mishina
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Explore the profile of Masayoshi Mishina including associated specialties, affiliations and a list of published articles.
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Articles
127
Citations
3829
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Recent Articles
1.
Suzuki N, Oota-Ishigaki A, Kaizuka T, Itoh M, Yamazaki M, Natsume R, et al.
Mol Neurobiol
. 2024 Apr;
61(11):9125-9135.
PMID: 38592586
Proper regulation of N-methyl-D-aspartate-type glutamate receptor (NMDA receptor) expression is responsible for excitatory synaptic functions in the mammalian brain. NMDA receptor dysfunction can cause various neuropsychiatric disorders and neurodegenerative diseases....
2.
Yamagishi A, Ikekubo Y, Mishina M, Ikeda K, Ide S
J Pharmacol Sci
. 2024 Feb;
154(3):203-208.
PMID: 38395521
Ketamine, an N-methyl-d-aspartate (NMDA) receptor antagonist, has attracted attention for its acute and sustained antidepressant effects in patients with depression. Hydroxynorketamine (HNK), a metabolite of ketamine, exerts antidepressant effects without...
3.
Vinnakota C, Schroeder A, Du X, Ikeda K, Ide S, Mishina M, et al.
J Neurosci Res
. 2023 Oct;
102(1):e25257.
PMID: 37814998
Noncompetitive NMDA receptor (NMDAR) antagonists like phencyclidine (PCP) and ketamine cause psychosis-like symptoms in healthy humans, exacerbate schizophrenia symptoms in people with the disorder, and disrupt a range of schizophrenia-relevant...
4.
Oota-Ishigaki A, Takao K, Yamada D, Sekiguchi M, Itoh M, Koshidata Y, et al.
Neuropsychopharmacology
. 2022 May;
47(12):2150-2159.
PMID: 35618841
Long-lasting fear-related disorders depend on the excessive retention of traumatic fear memory. We previously showed that the palmitoylation-dependent removal of synaptic α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors prevents hyperexcitation-based epileptic seizures and...
5.
Uemura T, Suzuki-Kouyama E, Kawase S, Kurihara T, Yasumura M, Yoshida T, et al.
Cell Rep
. 2022 Apr;
39(1):110624.
PMID: 35385735
Neurexins (NRXNs) are key presynaptic cell adhesion molecules that regulate synapse formation and function via trans-synaptic interaction with postsynaptic ligands. Here, we generate cerebellar granule cell (CGC)-specific Nrxn triple-knockout (TKO)...
6.
Han D, Hong I, Choi J, Park P, Baek J, Park H, et al.
Mol Brain
. 2021 Dec;
14(1):174.
PMID: 34876180
Ketamine, a non-competitive antagonist of the N-methyl-D-aspartate receptor (NMDAR), generates a rapidly-acting antidepressant effect. It exerts psychomimetic effects, yet demands a further investigation of its mechanism. Previous research showed that...
7.
Yoshida T, Yamagata A, Imai A, Kim J, Izumi H, Nakashima S, et al.
Nat Commun
. 2021 Mar;
12(1):1848.
PMID: 33758193
Neuroligin 3 (NLGN3) and neurexins (NRXNs) constitute a canonical transsynaptic cell-adhesion pair, which has been implicated in autism. In autism spectrum disorder (ASD) development of sociality can be impaired. However,...
8.
Ide S, Ikekubo Y, Mishina M, Hashimoto K, Ikeda K
Int J Neuropsychopharmacol
. 2019 May;
22(7):449-452.
PMID: 31135879
Although the N-methyl-D-aspartate receptor antagonist ketamine has attracted attention because of its rapid and sustained antidepressant effects in depressed patients, its side effects have raised some concerns. Ketamine is a...
9.
Hasegawa S, Yoshimi A, Mouri A, Uchida Y, Hida H, Mishina M, et al.
Neuropharmacology
. 2018 Dec;
148:107-116.
PMID: 30590060
The impairment of social behaviors induced by social defeat stress exposure as juveniles is resistant to some antidepressants and an antipsychotic, although the underlying mechanisms and/or therapeutic target are not...
10.
Itoh M, Okuno H, Yamada D, Yamashita M, Abe M, Natsume R, et al.
Neuropsychopharmacol Rep
. 2018 Dec;
39(1):61-66.
PMID: 30536651
Background: AMPA receptors predominantly mediate fast excitatory synaptic transmission in the mammalian brain. Post-translational protein S-palmitoylation of AMPA receptor GluA subunits at their C-termini reversibly controls the receptors trafficking to...