Masao Kakoki
Overview
Explore the profile of Masao Kakoki including associated specialties, affiliations and a list of published articles.
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Articles
33
Citations
1056
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Recent Articles
1.
Soomro A, Khajehei M, Li R, ONeil K, Zhang D, Gao B, et al.
Cell Mol Biol Lett
. 2023 Jan;
28(1):10.
PMID: 36717814
Background: TGFβ1 is a major profibrotic mediator in chronic kidney disease (CKD). Its direct inhibition, however, is limited by adverse effects. Inhibition of activins, also members of the TGFβ superfamily,...
2.
Kakoki M, Ramanathan P, Hagaman J, Grant R, Wilder J, Taylor J, et al.
Commun Biol
. 2021 Jun;
4(1):775.
PMID: 34163008
Patients with long-standing diabetes have a high risk for cardiac complications that is exacerbated by increased reactive oxygen species (ROS) production. We found that feeding cyanocobalamin (B12), a scavenger of...
3.
Hu P, Su H, Xiao H, Gou S, Herrera C, Alba M, et al.
J Am Soc Nephrol
. 2019 Nov;
31(2):297-307.
PMID: 31772138
Background: Myeloperoxidase-specific ANCA (MPO-ANCA) are implicated in the pathogenesis of vasculitis and GN. Kinins play a major role during acute inflammation by regulating vasodilatation and vascular permeability and by modulating...
4.
Kakoki M, Bahnson E, Hagaman J, Siletzky R, Grant R, Kayashima Y, et al.
JCI Insight
. 2019 Jun;
4(12).
PMID: 31217360
Engulfment and cell motility protein 1 (ELMO1) is part of a guanine nucleotide exchange factor for Ras-related C3 botulinum toxin substrate (Rac), and ELMO1 polymorphisms were identified to be associated...
5.
Li F, Kakoki M, Smid M, Boggess K, Wilder J, Hiller S, et al.
Hypertension
. 2018 Apr;
71(5):894-903.
PMID: 29610266
Endothelin-1 (ET-1) is implicated in the pathophysiology of preeclampsia. An association between an gene polymorphism with high ET-1 and preeclampsia was reported in humans, but their cause and effect relationships...
6.
Bai X, Mangum K, Kakoki M, Smithies O, Mack C, Taylor J
Small GTPases
. 2017 Nov;
11(3):194-203.
PMID: 29099324
Vascular resistance is a major determinant of BP and is controlled, in large part, by RhoA-dependent smooth muscle cell (SMC) contraction within small peripheral arterioles and previous studies from our...
7.
Chang A, Grant R, Tomita H, Kim H, Smithies O, Kakoki M
Proc Natl Acad Sci U S A
. 2016 Nov;
113(44):12538-12543.
PMID: 27791173
Increased levels of a cleaved form of prolactin (molecular weight 16 kDa) have been associated with preeclampsia. To study the effects of prolactin on blood pressure (BP), we generated male...
8.
Hathaway C, Chang A, Grant R, Kim H, Madden V, Bagnell Jr C, et al.
Proc Natl Acad Sci U S A
. 2016 Feb;
113(8):2218-22.
PMID: 26858454
Human genome-wide association studies have demonstrated that polymorphisms in the engulfment and cell motility protein 1 gene (ELMO1) are strongly associated with susceptibility to diabetic nephropathy. However, proof of causation...
9.
Chang A, Hathaway C, Smithies O, Kakoki M
Am J Physiol Renal Physiol
. 2016 Jan;
310(8):F689-F696.
PMID: 26719364
Transforming growth factor-β1 (TGF-β1) is established to be involved in the pathogenesis of diabetic nephropathy. The diabetic milieu enhances oxidative stress and induces the expression of TGF-β1. TGF-β1 promotes cell...
10.
Hathaway C, Gasim A, Grant R, Chang A, Kim H, Madden V, et al.
Proc Natl Acad Sci U S A
. 2015 Apr;
112(18):5815-20.
PMID: 25902541
Nephropathy develops in many but not all patients with long-standing type 1 diabetes. Substantial efforts to identify genotypic differences explaining this differential susceptibility have been made, with limited success. Here,...