Mary Guaraldi
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Explore the profile of Mary Guaraldi including associated specialties, affiliations and a list of published articles.
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20
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124
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Recent Articles
1.
Guaraldi M, Shea T
Open Neurol J
. 2018 Mar;
12:12-18.
PMID: 29541261
Objective: We examined genetic and dietary challenge on hippocampal oxidative damage. Mice expressing (ApoE+/+) or lacking apolipoprotein E (ApoE-/-) were maintained on a standard diet or a high fat /high...
2.
Shultz A, Lee S, Guaraldi M, Shea T, Yanco H
Open Neurol J
. 2017 Nov;
11:39-47.
PMID: 29151990
Background And Objective: The reductionist approach of neuronal cell culture has been useful for analyses of synaptic signaling. Murine cortical neurons in culture spontaneously form an network capable of transmitting...
3.
Therrien M, Vohnoutka R, Boumil E, Guaraldi M, Lee S, Shea T
Int J Dev Neurosci
. 2016 Oct;
55:66-71.
PMID: 27686511
The nervous system is composed of excitatory and inhibitory neurons. One major class of inhibitory neurons release the neurotransmitter γ-Aminobutyric acid (GABA). GABAergic inhibitory activity maintains the balance that is...
4.
Lee S, Zemianek J, Shultz A, Vo A, Maron B, Therrien M, et al.
Int J Dev Neurosci
. 2014 Aug;
38:184-94.
PMID: 25172170
Cultured embryonic neurons develop functional networks that transmit synaptic signals over multiple sequentially connected neurons as revealed by multi-electrode arrays (MEAs) embedded within the culture dish. Signal streams of ex...
5.
Radeke H, Purohit A, Harris T, Hanson K, Jones R, Hu C, et al.
ACS Med Chem Lett
. 2014 Jun;
2(9):650-5.
PMID: 24900360
A series of potent and selective β1-adrenoreceptor ligands were identified (IC50 range, 0.04-0.25 nM; β1/β2 selectivity range, 65-450-fold), labeled with the PET radioisotope fluorine-18 and evaluated in normal Sprague-Dawley rats....
6.
Yu M, Bozek J, Kagan M, Guaraldi M, Silva P, Azure M, et al.
Nucl Med Biol
. 2013 Apr;
40(5):682-8.
PMID: 23601914
Introduction: Released sympathetic neurotransmitter norepinephrine (NE) in the heart is cleared by neuronal uptake-1 and extraneuronal uptake-2 transporters. Cardiac uptake-1 and -2 expression varies among species, but the uptake-1 is...
7.
Zemianek J, Lee S, Guaraldi M, Shea T
Int J Dev Neurosci
. 2013 Apr;
31(5):308-10.
PMID: 23563174
A number of laboratories have modeled aspects of synaptic plasticity using neuronal networks established on micro-electrode arrays. Such studies demonstrate that external stimulation can increase or hasten maturation of network...
8.
Zemianek J, Shultz A, Lee S, Guaraldi M, Yanco H, Shea T
Int J Dev Neurosci
. 2012 Dec;
31(2):131-7.
PMID: 23220177
A predominance of excitatory activity, with protracted appearance of inhibitory activity, accompanies cortical neuronal development. It is unclear whether or not inhibitory neuronal activity is solicited exclusively by excitatory neurons...
9.
Deskus J, Dischino D, Mattson R, Ditta J, Parker M, Denhart D, et al.
Bioorg Med Chem Lett
. 2012 Sep;
22(21):6651-5.
PMID: 23010264
Based on a favorable balance between CRF-R1 affinity, lipophilicity and metabolic stability, compound 10 was evaluated for potential development as PET radioligand. Compound [(18)F]10 was prepared with high radiochemical purity...
10.
Zemianek J, Lee S, Guaraldi M, Shea T
Int J Dev Neurosci
. 2012 Aug;
30(7):602-6.
PMID: 22906544
Neuronal networks established on micro-electrode arrays provide useful models for synaptic plasticity. Whether or not this represents a facet of learning is debated since ex vivo networks are deprived of...