Mary Ellen Pease
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Explore the profile of Mary Ellen Pease including associated specialties, affiliations and a list of published articles.
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20
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988
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Recent Articles
1.
Madhoun S, Martins M, Korneva A, Johnson T, Kimball E, Quillen S, et al.
Exp Eye Res
. 2022 Dec;
226:109341.
PMID: 36476399
To identify changes in response to experimental intraocular pressure (IOP) elevation associated with the laminin α1 nmf223 mutation in mice. Laminin mutant (LM) mice (Lama1) and C57BL/6J (B6) mice in...
2.
Guan C, Pease M, Quillen S, Ling Y, Li X, Kimball E, et al.
Invest Ophthalmol Vis Sci
. 2022 Oct;
63(11):18.
PMID: 36269186
Purpose: To measure quantitatively changes in lamina cribrosa (LC) cell and connective tissue structure in human glaucoma eyes. Methods: We studied 27 glaucoma and 19 age-matched non-glaucoma postmortem eyes. In...
3.
Kimball E, Schaub J, Quillen S, Keuthan C, Pease M, Korneva A, et al.
PLoS One
. 2021 Feb;
16(2):e0244123.
PMID: 33529207
Purpose: To study aquaporin channel expression in astrocytes of the mouse optic nerve (ON) and the response to IOP elevation in mice lacking aquaporin 4 (AQP4 null). Methods: C57BL/6 (B6)...
4.
Korneva A, Schaub J, Jefferys J, Kimball E, Pease M, Nawathe M, et al.
Exp Eye Res
. 2020 May;
196:108035.
PMID: 32353427
Axonal transport blockade is an initial step in retinal ganglion cell (RGC) degeneration in glaucoma and targeting maintenance of normal axonal transport could confer neuroprotection. We present an objective, quantitative...
5.
Pitha I, Oglesby E, Chow A, Kimball E, Pease M, Schaub J, et al.
Transl Vis Sci Technol
. 2018 Nov;
7(6):6.
PMID: 30479877
Purpose: We evaluated prevention of transforming growth factor β (TGFβ)-induced transdifferentiation of cultured scleral fibroblasts to myofibroblasts by rho-associated protein kinase (ROCK) inhibitors. Additionally, we tested whether local delivery of...
6.
Pitha I, Kimball E, Oglesby E, Pease M, Fu J, Schaub J, et al.
Transl Vis Sci Technol
. 2018 Apr;
7(2):13.
PMID: 29616152
Purpose: To determine if one injection of a sustained release formulation of dorzolamide in biodegradable microparticles (DPP) reduces retinal ganglion cell (RGC) loss in a rat model of glaucoma. Methods:...
7.
Quigley H, Pitha I, Welsbie D, Nguyen C, Steinhart M, Nguyen T, et al.
PLoS One
. 2015 Oct;
10(10):e0141137.
PMID: 26505191
Purpose: To determine if oral losartan treatment decreases the retinal ganglion cell (RGC) death caused by experimental intraocular pressure (IOP) elevation in mice. Methods: We produced IOP increase in CD1...
8.
Pease M, Zack D, Berlinicke C, Bloom K, Cone F, Wang Y, et al.
Invest Ophthalmol Vis Sci
. 2008 Dec;
50(5):2194-200.
PMID: 19060281
Purpose: To assess the neuroprotective effect of virally mediated overexpression of ciliary-derived neurotrophic factor (CNTF) and brain-derived neurotrophic factor (BDNF) in experimental rat glaucoma. Methods: Laser-induced glaucoma was produced in...
9.
Ueno S, Pease M, Wersinger D, Masuda T, Vinores S, Licht T, et al.
J Cell Physiol
. 2008 Jun;
217(1):13-22.
PMID: 18543272
Several ocular diseases complicated by neovascularization are being treated by repeated intraocular injections of vascular endothelial growth factor (VEGF) antagonists. While substantial benefits have been documented, there is concern that...
10.
Martin K, Quigley H, Valenta D, Kielczewski J, Pease M
Exp Eye Res
. 2006 Mar;
83(2):255-62.
PMID: 16546168
Acute intraocular pressure (IOP) elevation causes accumulation of retrogradely-transported brain derived neurotrophic factor and its receptor at the optic nerve head (ONH) in rats and monkeys. Obstruction of axonal transport...