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Martin S Denzel

Explore the profile of Martin S Denzel including associated specialties, affiliations and a list of published articles. Areas
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Articles 28
Citations 1041
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Recent Articles
1.
Wester L, Lanjuin A, Bruckisch E, Perez-Matos M, Stine P, Heintz C, et al.
Cell Rep Methods . 2023 Apr; 3(3):100433. PMID: 37056370
Here, we introduce a single-copy knockin translating ribosome immunoprecipitation (SKI TRIP) toolkit, a collection of strains engineered by CRISPR in which tissue-specific expression of FLAG-tagged ribosomal subunit protein RPL-22 is...
2.
Tandon V, Moreno R, Allmeroth K, Quinn J, Wiley S, Nicely L, et al.
Biosci Rep . 2023 Jan; 43(1). PMID: 36622366
Preserving proteostasis is a major survival mechanism for cancer. Dual specificity tyrosine phosphorylation-regulated kinase 2 (DYRK2) is a key oncogenic kinase that directly activates the transcription factor heat-shock factor 1...
3.
Allmeroth K, Hartman M, Purrio M, Mesaros A, Denzel M
Aging Cell . 2022 Sep; 21(10):e13711. PMID: 36124412
Glucosamine feeding and genetic activation of the hexosamine biosynthetic pathway (HBP) have been linked to improved protein quality control and lifespan extension. However, as an energy sensor, the HBP has...
4.
Derisbourg M, Hartman M, Denzel M
Nat Aging . 2022 Feb; 1(9):760-768. PMID: 35146440
Healthy aging requires the coordination of numerous stress signaling pathways that converge on the protein homeostasis network. The Integrated Stress Response (ISR) is activated by diverse stimuli, leading to phosphorylation...
5.
Guerrero G, Derisbourg M, Mayr F, Wester L, Giorda M, Dinort J, et al.
Elife . 2021 Aug; 10. PMID: 34448454
Longevity is often associated with stress resistance, but whether they are causally linked is incompletely understood. Here we investigate chemosensory-defective mutants that are long-lived and stress resistant. We find that...
6.
Allmeroth K, Denzel M
J Invest Dermatol . 2021 Aug; 141(9):2105-2107. PMID: 34420674
Polyamines have been implicated in skin tumorigenesis; however, their role in epidermal homeostasis remains obscure. In a new article in the Journal of Investigative Dermatology, Rahim et al. (2021) report...
7.
Allmeroth K, Kim C, Annibal A, Pouikli A, Koester J, Derisbourg M, et al.
J Cell Sci . 2021 May; 134(9). PMID: 33973637
Stem cell differentiation is accompanied by increased mRNA translation. The rate of protein biosynthesis is influenced by the polyamines putrescine, spermidine and spermine, which are essential for cell growth and...
8.
Ruegenberg S, Mayr F, Atanassov I, Baumann U, Denzel M
Nat Commun . 2021 Apr; 12(1):2176. PMID: 33846315
The hexosamine pathway (HP) is a key anabolic pathway whose product uridine 5'-diphospho-N-acetyl-D-glucosamine (UDP-GlcNAc) is an essential precursor for glycosylation processes in mammals. It modulates the ER stress response and...
9.
Derisbourg M, Wester L, Baddi R, Denzel M
Nat Commun . 2021 Mar; 12(1):1678. PMID: 33723245
Protein homeostasis is modulated by stress response pathways and its deficiency is a hallmark of aging. The integrated stress response (ISR) is a conserved stress-signaling pathway that tunes mRNA translation...
10.
Bonekamp N, Peter B, Hillen H, Felser A, Bergbrede T, Choidas A, et al.
Nature . 2020 Dec; 588(7839):712-716. PMID: 33328633
Altered expression of mitochondrial DNA (mtDNA) occurs in ageing and a range of human pathologies (for example, inborn errors of metabolism, neurodegeneration and cancer). Here we describe first-in-class specific inhibitors...