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Martin N Perkins

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Articles 6
Citations 107
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Recent Articles
1.
Serrano A, Mo G, Grant R, Pare M, ODonnell D, Yu X, et al.
J Neurosci . 2012 Aug; 32(34):11890-6. PMID: 22915129
Evidence suggesting the involvement of P2X2 and P2X3 in chronic pain has been obtained mostly from rodent models. Here we show that rodents may be poor predictors of P2X3 pharmacology...
2.
Martino G, Puma C, Yu X, Gilbert A, Coupal M, Markoglou N, et al.
Pain . 2011 Oct; 152(12):2852-2860. PMID: 22018972
The role of muscarinic receptor subtype-1 (M1) in chronic pain is unclear. In an attempt to gain an understanding of its role, we have tested xanomeline, an M1/M4-preferring agonist, together...
3.
Serrano A, Pare M, McIntosh F, Elmes S, Martino G, Jomphe C, et al.
Mol Pain . 2010 Dec; 6:90. PMID: 21143971
Background: The CCR2/CCL2 system has been identified as a regulator in the pathogenesis of neuropathy-induced pain. However, CCR2 target validation in analgesia and the mechanism underlying antinociception produced by CCR2...
4.
Yu X, Cao C, Martino G, Puma C, Morinville A, St-Onge S, et al.
Pain . 2010 Aug; 151(2):337-344. PMID: 20696525
Cannabinoids are analgesic in man, but their use is limited by their psychoactive properties. One way to avoid cannabinoid receptor subtype 1 (CB1R)-mediated central side-effects is to develop CB1R agonists...
5.
Cao C, Yu X, Dray A, Filosa A, Perkins M
Pain . 2003 Aug; 104(3):609-616. PMID: 12927633
Although the neuropeptide neuromedin U (NMU) was first isolated from the spinal cord, its actions in this site are unknown. The recent identification of the NMU receptor subtype 2 (NMU2R)...
6.
Dziadulewicz E, Ritchie T, Hallett A, Snell C, Davies J, Wrigglesworth R, et al.
J Med Chem . 2002 May; 45(11):2160-72. PMID: 12014954
The 1-(2-nitrophenyl)thiosemicarbazide (TSC) derivative, (S)-1-[4-(4-benzhydrylthiosemicarbazido)-3-nitrobenzenesulfonyl]pyrrolidine-2-carboxylic acid [2-[(2-dimethylaminoethyl)methylamino]ethyl]amide (bradyzide; (S)-4), was recently disclosed as a novel, potent, orally active nonpeptide bradykinin (BK) B2 receptor antagonist. The compound inhibited the specific binding...