Martin Lenicek
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Explore the profile of Martin Lenicek including associated specialties, affiliations and a list of published articles.
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53
Citations
553
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Recent Articles
1.
Dusek J, Mejdrova I, Dohnalova K, Smutny T, Chalupsky K, Krutakova M, et al.
Nat Commun
. 2025 Feb;
16(1):1418.
PMID: 39915454
Constitutive androstane receptor (CAR) and pregnane X receptor (PXR) are closely related nuclear receptors with overlapping regulatory functions in xenobiotic clearance but distinct roles in endobiotic metabolism. Car activation has...
2.
Koelfat K, Schaap F, van Mierlo K, Lenicek M, Sauer I, van der Kroft G, et al.
Hepatol Commun
. 2024 Jun;
8(6).
PMID: 38836805
Background: Extended liver resection is the only treatment option for perihilar cholangiocarcinoma (pCCA). Bile salts and the gut hormone FGF19, both promoters of liver regeneration (LR), have not been investigated...
3.
Ay U, Lenicek M, Haider R, Classen A, van Eijk H, Koelfat K, et al.
Hepatol Commun
. 2024 Mar;
8(4).
PMID: 38517202
Background: Bile salts of hepatic and microbial origin mediate interorgan cross talk in the gut-liver axis. Here, we assessed whether the newly discovered class of microbial bile salt conjugates (MBSCs)...
4.
Sevela S, Meisnerova E, Vecka M, Vavrova L, Rychlikova J, Lenicek M, et al.
Nutrients
. 2024 Feb;
16(4).
PMID: 38398809
(1) Objectives Intestinal failure in home parenteral nutrition patients (HPNPs) results in oxidative stress and liver damage. This study investigated how a high dose of fish oil (FO) added to...
5.
Gurbuz B, Guldiken N, Reuken P, Fu L, Remih K, Preisinger C, et al.
Hepatol Int
. 2023 Jan;
17(3):698-708.
PMID: 36652164
Background And Aim: Since hepatocytes produce majority of serum proteins, patients with cirrhosis display substantial alterations in the serum proteome. The aim of the current study was to characterize these...
6.
Zizalova K, Novakova B, Vecka M, Petrtyl J, Lanska V, Pelinkova K, et al.
Liver Int
. 2022 Nov;
43(4):888-895.
PMID: 36433660
Background & Aims: Severity of portal hypertension is usually quantified by measuring the hepatic venous pressure gradient (HVPG). However, due to its invasiveness, alternative markers are being sought. Bile acids...
7.
Jensen Pedersen K, Haange S, Zizalova K, Viehof A, Clavel T, Lenicek M, et al.
Microorganisms
. 2022 Oct;
10(10).
PMID: 36296301
Bile acids are crucial for the uptake of dietary lipids and can shape the gut-microbiome composition. This latter function is associated with the toxicity of bile acids and can be...
8.
Woronyczova J, Novakova M, Lenicek M, Batovsky M, Bolek E, Cifkova R, et al.
Sports Med Open
. 2022 Jun;
8(1):84.
PMID: 35759151
Objectives: Bilirubin is a potent endogenous antioxidant and immunomodulating substance, which is also implicated in both cell signalling and various metabolic pathways. Mild elevation of systemic bilirubin concentrations provides substantial...
9.
Ay U, Lenicek M, Classen A, Olde Damink S, Bolm C, Schaap F
Metabolites
. 2022 Feb;
12(2).
PMID: 35208250
Biotransformation of host bile salts by gut microbes results in generation of secondary bile salt species that have biological and physicochemical properties that are distinct from the parent compounds. There...
10.
Smid V, Dvorak K, Sedivy P, Kosek V, Lenicek M, Dezortova M, et al.
Hepatol Commun
. 2022 Feb;
6(6):1336-1349.
PMID: 35147302
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease. n-3 polyunsaturated fatty acids (n-3-PUFAs) have been reported to ameliorate the progression of NAFLD in experimental studies; however,...