Martin G Weigert
Overview
Explore the profile of Martin G Weigert including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
100
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0
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Recent Articles
1.
Wang Y, Liu J, Akatsu C, Zhang R, Zhang H, Zhu H, et al.
Proc Natl Acad Sci U S A
. 2022 Aug;
119(36):e2205629119.
PMID: 36037365
Elimination of autoreactive developing B cells is an important mechanism to prevent autoantibody production. However, how B cell receptor (BCR) signaling triggers apoptosis of immature B cells remains poorly understood....
2.
Radic M, Weigert M, Khan S, Han J, Kalinina O, Luning Prak E
Proc Natl Acad Sci U S A
. 2013 Jul;
110(29):11958-63.
PMID: 23818632
Light (L) chains that edit anti-DNA heavy (H) chains rescue B-cell development by suppressing DNA binding. However, exceptional editor L chains allow B cells to reach splenic compartments even though...
3.
Kishi Y, Higuchi T, Phoon S, Sakamaki Y, Kamiya K, Riemekasten G, et al.
Proc Natl Acad Sci U S A
. 2012 May;
109(20):7811-6.
PMID: 22547827
CD40L is excessively produced in both human and murine lupus and plays a role in lupus pathogenesis. To address how excess CD40L induces autoantibody production, we crossed CD40L-transgenic mice with...
4.
Meng W, Yunk L, Wang L, Maganty A, Xue E, Cohen P, et al.
J Immunol
. 2011 Jul;
187(4):1835-44.
PMID: 21746964
B cells are subjected to selection at multiple checkpoints during their development. The selection of Ab H chains is difficult to study because of the large diversity of the CDR3....
5.
Kalinina O, Doyle-Cooper C, Miksanek J, Meng W, Prak E, Weigert M
Proc Natl Acad Sci U S A
. 2011 Apr;
108(17):7125-30.
PMID: 21471456
Pathogenic anti-DNA antibodies expressed in systemic lupus erythematosis bind DNA mainly through electrostatic interactions between the positively charged Arg residues of the antibody complementarity determining region (CDR) and the negatively...
6.
Doyle C, Han J, Weigert M, Luning Prak E
Proc Natl Acad Sci U S A
. 2006 Jul;
103(30):11264-9.
PMID: 16847259
To investigate the manner in which B cells with lambda light (L) chains undergo receptor editing, we have studied hybridoma panels from 56R/kappa-deleted (kdel) mice. 56R/kdel mice only produce four...
7.
Sekiguchi D, Yunk L, Gary D, Charan D, Srivastava B, Allman D, et al.
J Immunol
. 2006 May;
176(11):6879-87.
PMID: 16709848
Tolerance to dsDNA is broken in mice with a high-affinity anti-DNA H chain transgene, 56R, on the C57BL/6 background (B6.56R). B6.56R produce more anti-dsDNA Abs than BALBc.56R. To investigate how...