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Martin Fussenegger

Explore the profile of Martin Fussenegger including associated specialties, affiliations and a list of published articles. Areas
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Articles 308
Citations 6904
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Recent Articles
1.
Huang J, Teixeira A, Gao T, Xue S, Xie M, Fussenegger M
Nat Commun . 2025 Feb; 16(1):2028. PMID: 40016240
Current small-molecule-regulated synthetic gene switches face clinical limitations such as cytotoxicity, long-term side-effects and metabolic disturbances. Here, we describe an advanced synthetic platform inducible by risk-free input medication (ASPIRIN), which...
2.
Ribezzi D, Zegwaart J, Van Gansbeke T, Tejo-Otero A, Florczak S, Aerts J, et al.
Adv Mater . 2025 Feb; :e2409355. PMID: 40012257
Volumetric Bioprinting (VBP), enables to rapidly build complex, cell-laden hydrogel constructs for tissue engineering and regenerative medicine. Light-based tomographic manufacturing enables spatial-selective polymerization of a bioresin, resulting in higher throughput...
3.
Mahameed M, Xue S, Danuser B, Hamri G, Xie M, Fussenegger M
Nat Biomed Eng . 2025 Feb; PMID: 39953326
Gene therapies and cell therapies require precise, reversible and patient-friendly control over the production of therapeutic proteins. Here we present a fully human nitric-oxide-responsive gene-regulation system for the on-demand and...
4.
Mansouri M, Fussenegger M
Cell Chem Biol . 2025 Jan; PMID: 39879984
Human body cells and our daily electronic devices both communicate information within their distinct worlds by regulating the flow of electrons across specified membranes. While electronic devices depend on the...
5.
Teixeira A, Franko N, Fussenegger M
Biotechnol Bioeng . 2025 Jan; 122(4):1051-1061. PMID: 39801452
Human pluripotent stem cells (hPSCs) can be differentiated in vitro to an increasing number of mature cell types, presenting significant promise for addressing a wide range of diseases and studying...
6.
Guha Ray P, Rajasekaran R, Pratihar B, De S, Dhara S, Fussenegger M
Adv Sci (Weinh) . 2025 Jan; 12(9):e2412257. PMID: 39792704
Neo-vascularization plays a key role in achieving long-term viability of engineered cells contained in medical implants used in precision medicine. Moreover, strategies to promote neo-vascularization around medical implants may also...
7.
Unal G, Fussenegger M
Curr Opin Biotechnol . 2025 Jan; 91:103249. PMID: 39788045
All cells are innately equipped with systems to detect and respond to electrical inputs in the form of reactive oxygen species, redox signaling, or membrane depolarization through ion exchange. Electrogenetics...
8.
Maity D, Guha Ray P, Fussenegger M
Adv Mater . 2024 Aug; 36(44):e2408537. PMID: 39210629
Closed-loop control systems for precise control of therapeutic gene expression are promising candidates for personalized treatment of chronic ailments such as diabetes. Pancreatic iβ-cells are engineered with blue-light-inducible melanopsin to...
9.
Huang J, Fussenegger M
Trends Biotechnol . 2024 Aug; 43(1):16-42. PMID: 39179464
In recent decades, the field of synthetic biology has witnessed remarkable progress, driving advances in both research and practical applications. One pivotal area of development involves the design of transgene...
10.
Galvan S, Teixeira A, Fussenegger M
Biotechnol Bioeng . 2024 Jun; 121(10):2987-3000. PMID: 38867466
Synthetic biology aims to contribute to the development of next-generation patient-specific cell-based therapies for chronic diseases especially through the construction of sophisticated synthetic gene switches to enhance the safety and...