Mark Mitchnick
Overview
Explore the profile of Mark Mitchnick including associated specialties, affiliations and a list of published articles.
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11
Citations
125
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Recent Articles
1.
Kleinman D, Iqbal S, Ghosh A, Ogle S, Kaja S, Mitchnick M, et al.
J Ocul Pharmacol Ther
. 2024 Jun;
40(7):419-427.
PMID: 38935528
Antibody-drug conjugates (ADCs) are a relatively recent advance in the delivery of chemotherapeutics that improve targeting of cytotoxic agents. However, despite their antitumor activity, severe ocular adverse effects, including vision...
2.
Lee R, Mitchnick M
Curr Protoc Chem Biol
. 2017 Dec;
9(4):306-314.
PMID: 29241294
When a drug candidate-i.e., a new chemical entity (NCE) or new molecular entity (NME)-is discovered, there is a requirement to identify a vehicle for in vitro and/or in vivo evaluation...
3.
Loxley A, Mitchnick M, Okoh O, McConnell J, Goldman L, Morgan C, et al.
Drug Deliv Transl Res
. 2015 Mar;
1(3):247-55.
PMID: 25788243
Ethylene vinyl acetate intravaginal rings (IVRs) were prepared by hot-melt compounding and injection moulding. The IVRs contained various levels of the antiretroviral drug UC781 and the contraceptive hormone levonorgestrel. The...
4.
Gensheimer W, Kleinman D, Gonzalez M, Sobti D, Cooper E, Smits G, et al.
J Ocul Pharmacol Ther
. 2012 May;
28(5):473-8.
PMID: 22554205
Purpose: To evaluate the effectiveness of glycerin 1% formulated with the novel and proprietary ophthalmic excipient poly(l-lysine)-graft-poly(ethylene glycol) (PLL-g-PEG) (Eyeon Particle Sciences LLC) in extending tear film break-up time (TFBUT)...
5.
Forbes C, Lowry D, Geer L, Veazey R, Shattock R, Klasse P, et al.
J Control Release
. 2011 Aug;
156(2):161-9.
PMID: 21864598
Aqueous semi-solid polymeric gels, such as those based on hydroxyethylcellulose (HEC) and polyacrylic acid (e.g. Carbopol®), have a long history of use in vaginal drug delivery. However, despite their ubiquity,...
6.
Arias M, Loxley A, Eatmon C, Roey G, Fairhurst D, Mitchnick M, et al.
Vaccine
. 2010 Dec;
29(6):1258-69.
PMID: 21145913
Induction of humoral responses to HIV at mucosal compartments without inflammation is important for vaccine design. We developed charged wax nanoparticles that efficiently adsorb protein antigens and are internalized by...
7.
Nel A, Coplan P, Smythe S, McCord K, Mitchnick M, Kaptur P, et al.
AIDS Res Hum Retroviruses
. 2010 Sep;
26(11):1181-90.
PMID: 20854207
Unlabelled: To assess the pharmacokinetics of dapivirine in plasma and dapivirine concentrations in cervicovaginal fluids (CVF) and cervicovaginal tissues following vaginal administration of dapivirine microbicide gel in healthy, HIV-negative women...
8.
Rosenberg Z, Nel A, Heyward W, Mitchnick M
Curr Opin HIV AIDS
. 2009 Apr;
1(6):514-9.
PMID: 19372855
Purpose Of Review: As the HIV/AIDS pandemic continues, the development of new prevention technologies is urgently needed. Microbicides, products applied to genital mucosal surfaces, are being developed to reduce the...
9.
Cain C, Schroeder F, Shankel S, Mitchnick M, Schmertzler M, Bricker N
Proc Natl Acad Sci U S A
. 2007 Nov;
104(45):17873-8.
PMID: 17978185
Hormonal regulation of salt excretion and water balance by the kidneys is well documented. Before 1961, it was widely believed that the glomerular filtration rate and the steroid hormone aldosterone...
10.
Nuttall J, Romano J, Douville K, Galbreath C, Nel A, Heyward W, et al.
Infect Dis Clin North Am
. 2007 May;
21(1):219-39, x.
PMID: 17502237
Topical microbicides are self-administered products for prevention of HIV transmission, and they present one of the most promising strategies for combating the HIV-AIDS epidemic. The development of microbicides is a...