Mark C Markowski
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Explore the profile of Mark C Markowski including associated specialties, affiliations and a list of published articles.
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62
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Recent Articles
1.
Aber E, Carducci M, Paller C, Denmeade S, Rourke K, Marshall C, et al.
Prostate
. 2024 Dec;
85(4):391-394.
PMID: 39709533
Introduction: Non-castrating therapies are an unmet clinical need for patients with advanced prostate cancer. To maximize quality of life and prioritize cardiovascular health, we investigated SGLT2 inhibitors as a non-castrating...
2.
Markowski M, Ren Y, Tierney M, Royce T, Yamashita R, Croucher D, et al.
Eur Urol Oncol
. 2024 Dec;
PMID: 39665917
Background And Objective: Owing to the expansion of treatment options for metastatic hormone-sensitive prostate cancer (mHSPC) and an appreciation of clinical subgroups with differential prognosis and treatment responses, prognostic and...
3.
Singh R, Thotakura A, Alati S, Lisok A, Jiang Z, Merino V, et al.
Front Oncol
. 2024 Sep;
14:1432286.
PMID: 39324008
Introduction: Renal cell carcinoma (RCC) represents cancer originating from the renal epithelium and accounts for > 90% of cancers in the kidney. Prostate-specific membrane antigen (PSMA) is overexpressed in tumor-associated...
4.
Gafita A, Voter A, Shesadri S, Spitz A, Marshall C, Rowe S, et al.
J Nucl Med
. 2024 Sep;
65(11):1724-1730.
PMID: 39299783
[Lu]Lu-PSMA-617 was approved by the U.S. Food and Drug Administration for patients with prostate-specific membrane antigen (PSMA)-positive metastatic castration-resistant prostate cancer (mCRPC). Since the time of regulatory approval, however, real-world...
5.
Marshall C, Teply B, Lu J, Oliveira L, Wang H, Mao S, et al.
JAMA Oncol
. 2024 Aug;
10(10):1400-1408.
PMID: 39172479
Importance: Olaparib is a poly(adenosine diphosphate-ribose) polymerase inhibitor that provides benefit in combination with hormonal therapies in patients with metastatic prostate cancer who harbor homologous recombination repair (HRR) alterations. Its...
6.
Paller C, Zahurak M, Mandl A, Metri N, Lalji A, Heath E, et al.
Cancer Res Commun
. 2024 Jul;
4(8):2174-2182.
PMID: 39076107
Significance: This is the first randomized, placebo-controlled, double-blind trial to evaluate HDIVC in cancer treatment. The addition of HDIVC to docetaxel in patients with mCRPC does not improve PSA response,...
7.
Markowski M, Sternberg C, Wang H, Wang T, Linville L, Marshall C, et al.
Oncologist
. 2024 Jun;
29(9):794-800.
PMID: 38885246
Background: The activity of PARP inhibitors (PARPi) in patients with homologous recombination repair (HRR) mutations and metastatic castration-resistant prostate cancer has been established. We hypothesized that the benefit of PARPi...
8.
Marshall C, Gondek L, Daniels V, Lu C, Pasca S, Xie J, et al.
Prostate
. 2024 Apr;
84(10):954-958.
PMID: 38641986
Background: Poly ADP-ribose polymerase (PARP) inhibitors are approved for the treatment of some men with advanced prostate cancer. Rare but serious side effects include myelodysplastic syndrome (MDS) and acute myeloid...
9.
Markowski M, Taplin M, Aggarwal R, Sena L, Wang H, Qi H, et al.
Nat Commun
. 2024 Jan;
15(1):14.
PMID: 38167882
Cyclic high-dose testosterone administration, known as bipolar androgen therapy (BAT), is a treatment strategy for patients with metastatic castration-resistant prostate cancer (mCRPC). Here, we report the results of a multicenter,...
10.
Chen J, Zheng Q, Hicks J, Trabzonlu L, Ozbek B, Jones T, et al.
JCI Insight
. 2023 Nov;
8(24).
PMID: 37971875
Increased mitochondrial function may render some cancers vulnerable to mitochondrial inhibitors. Since mitochondrial function is regulated partly by mitochondrial DNA copy number (mtDNAcn), accurate measurements of mtDNAcn could help reveal...