Mark Busbridge
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Explore the profile of Mark Busbridge including associated specialties, affiliations and a list of published articles.
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710
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Recent Articles
1.
Hildebrand S, Busbridge M, Duncan N, Tam F, Ashby D
Hemodial Int
. 2022 Jul;
26(4):519-526.
PMID: 35833334
Anemia protocols for hemodialysis patients usually titrate erythropoietin (ESA) according to hemoglobin and iron according to a threshold of ferritin, with variable response seen. A universally optimum threshold for ferritin...
2.
Comninos A, Hansen M, Courtney A, Choudhury S, Yang L, Mills E, et al.
J Clin Endocrinol Metab
. 2022 Mar;
107(6):1529-1540.
PMID: 35244717
Context: Osteoporosis results from disturbances in bone formation and resorption. Recent nonhuman data suggest that the reproductive hormone kisspeptin directly stimulates osteoblast differentiation in vitro and thus could have clinical...
3.
Mehta K, Busbridge M, Patel V, Farnaud S
Mol Cell Biochem
. 2020 Mar;
468(1-2):121-128.
PMID: 32185675
Hepcidin is the master regulator of systemic iron homeostasis and its dysregulation is observed in several chronic liver diseases. Unlike the extracellular iron-sensing mechanisms, the intracellular iron-sensing mechanisms in the...
4.
Ashby D, Busbridge M, Hildebrand S, Clarke C, Aldous G, Palan M, et al.
Clin Nephrol
. 2017 Mar;
87 (2017)(5):231-236.
PMID: 28291504
Background: The discovery of hepcidin, the hormone regulating iron absorption and transport, has improved the understanding of anemia and erythropoietin treatment. Excessive hepcidin signaling causes anemia in chronic inflammatory conditions...
5.
Mehta K, Busbridge M, Renshaw D, Evans R, Farnaud S, Patel V
Blood Cells Mol Dis
. 2016 Sep;
61:37-45.
PMID: 27667164
Hepcidin is the key regulator of systemic iron homeostasis. The iron-sensing mechanisms and the role of intracellular iron in modulating hepatic hepcidin secretion are unclear. Therefore, we created a novel...
6.
Can Iron Treatments Aggravate Epistaxis in Some Patients With Hereditary Hemorrhagic Telangiectasia?
Shovlin C, Gilson C, Busbridge M, Patel D, Shi C, Dina R, et al.
Laryngoscope
. 2016 Apr;
126(11):2468-2474.
PMID: 27107394
Objectives/hypothesis: To examine whether there is a rationale for iron treatments precipitating nosebleeds (epistaxis) in a subgroup of patients with hereditary hemorrhagic telangiectasia (HHT). Study Design: Survey evaluation of HHT...
7.
Mehta K, Greenwell P, Renshaw D, Busbridge M, Garcia M, Farnaud S, et al.
Blood Cells Mol Dis
. 2015 Jul;
55(2):110-8.
PMID: 26142326
Iron overload coupled with low hepcidin levels are characteristics of hereditary haemochromatosis. To understand the role of transferrin receptor (TFR) and intracellular iron in hepcidin secretion, Chinese hamster ovary transferrin...
8.
Wagner M, Ashby D, Kurtz C, Alam A, Busbridge M, Raff U, et al.
PLoS One
. 2015 Apr;
10(4):e0123072.
PMID: 25894587
Background: Anemia is common and is associated with impaired clinical outcomes in diabetic chronic kidney disease (CKD). It may be explained by reduced erythropoietin (EPO) synthesis, but recent data suggest...
9.
Cotroneo E, Ashek A, Wang L, Wharton J, Dubois O, Bozorgi S, et al.
Circ Res
. 2015 Mar;
116(10):1680-90.
PMID: 25767292
Rationale: Iron deficiency without anemia is prevalent in patients with idiopathic pulmonary arterial hypertension and associated with reduced exercise capacity and survival. Objectives: We hypothesized that iron deficiency is involved...
10.
Sam A, Sleeth M, Thomas E, Ismail N, Daud N, Chambers E, et al.
J Clin Endocrinol Metab
. 2014 Dec;
100(3):1048-52.
PMID: 25490276
Context And Objective: No current biomarker can reliably predict visceral and liver fat content, both of which are risk factors for cardiovascular disease. Vagal tone has been suggested to influence...