Mark A Ungless
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Explore the profile of Mark A Ungless including associated specialties, affiliations and a list of published articles.
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43
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2803
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Recent Articles
11.
Paul E, Kalk E, Tossell K, Irvine E, Franks N, Wisden W, et al.
eNeuro
. 2018 Nov;
5(5).
PMID: 30456293
GABA neurons in the VTA and SNc play key roles in reward and aversion through their local inhibitory control of dopamine neuron activity and through long-range projections to several target...
12.
Sandhu E, Fernando A, Irvine E, Tossell K, Kokkinou M, Glegola J, et al.
eNeuro
. 2018 May;
5(2).
PMID: 29766048
Salt intake is an essential dietary requirement, but excessive consumption is implicated in hypertension and associated conditions. Little is known about the neural circuit mechanisms that control motivation to consume...
13.
Apps J, Carreno G, Gonzalez-Meljem J, Haston S, Guiho R, Cooper J, et al.
Acta Neuropathol
. 2018 Mar;
135(5):757-777.
PMID: 29541918
Adamantinomatous craniopharyngiomas (ACPs) are clinically challenging tumours, the majority of which have activating mutations in CTNNB1. They are histologically complex, showing cystic and solid components, the latter comprised of different...
14.
Viskaitis P, Irvine E, Smith M, Choudhury A, Alvarez-Curto E, Glegola J, et al.
Cell Rep
. 2017 Dec;
21(12):3559-3572.
PMID: 29262334
Feeding requires the integration of homeostatic drives with emotional states relevant to food procurement in potentially hostile environments. The ventromedial hypothalamus (VMH) regulates feeding and anxiety, but how these are...
15.
Ferrai C, Torlai Triglia E, Risner-Janiczek J, Rito T, Rackham O, de Santiago I, et al.
Mol Syst Biol
. 2017 Oct;
13(10):946.
PMID: 29038337
Polycomb repression in mouse embryonic stem cells (ESCs) is tightly associated with promoter co-occupancy of RNA polymerase II (RNAPII) which is thought to prime genes for activation during early development....
16.
Iyer R, Ungless M, Faisal A
Sci Rep
. 2017 Jul;
7(1):5248.
PMID: 28701749
Dopamine neurons in the substantia nigra pars compacta and ventral tegmental area regulate behaviours such as reward-related learning, and motor control. Dysfunction of these neurons is implicated in Schizophrenia, addiction...
17.
Dougalis A, Matthews G, Liss B, Ungless M
J Comput Neurosci
. 2017 Apr;
42(3):275-305.
PMID: 28367595
Dopamine (DA) neurons of the ventrolateral periaqueductal gray (vlPAG) and dorsal raphe nucleus (DRN) fire spontaneous action potentials (APs) at slow, regular patterns in vitro but a detailed account of...
18.
Van de Pette M, Abbas A, Feytout A, McNamara G, Bruno L, To W, et al.
Cell Rep
. 2017 Feb;
18(5):1090-1099.
PMID: 28147266
Imprinted genes are regulated according to parental origin and can influence embryonic growth and metabolism and confer disease susceptibility. Here, we designed sensitive allele-specific reporters to non-invasively monitor imprinted Cdkn1c...
19.
Abdul Rahman N, Greenwood S, Brett R, Tossell K, Ungless M, Plevin R, et al.
J Neurosci
. 2016 Feb;
36(8):2348-54.
PMID: 26911683
Mitogen-activated protein kinases (MAPKs) regulate brain function and their dysfunction is implicated in a number of brain disorders, including Alzheimer's disease. Thus, there is great interest in understanding the signaling...
20.
Matthews G, Nieh E, Vander Weele C, Halbert S, Pradhan R, Yosafat A, et al.
Cell
. 2016 Feb;
164(4):617-31.
PMID: 26871628
The motivation to seek social contact may arise from either positive or negative emotional states, as social interaction can be rewarding and social isolation can be aversive. While ventral tegmental...