Marius Regin
Overview
Explore the profile of Marius Regin including associated specialties, affiliations and a list of published articles.
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Articles
10
Citations
35
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Recent Articles
1.
Lei Y, Duong M, Krivec N, Janssens C, Regin M, Huyghebaert A, et al.
Cell Prolif
. 2025 Feb;
:e13813.
PMID: 39908990
Chromosomal abnormalities acquired during cell culture can compromise the differentiation potential of human pluripotent stem cells (hPSCs). In this work, we identified a diminished differentiation capacity to retinal progenitor cells...
2.
Van Der Kelen A, Li Piani L, Mertens J, Regin M, Couvreu de Deckersberg E, Van de Velde H, et al.
Hum Reprod Open
. 2025 Jan;
2025(1):hoae074.
PMID: 39830711
Study Question: Is there an association between different mitochondrial DNA (mtDNA) genotypes and female infertility or ovarian response, and is the appearance of variants in the oocytes favored by medically...
3.
Regin M, Lei Y, Couvreu de Deckersberg E, Janssens C, Huyghebaert A, Guns Y, et al.
Elife
. 2024 Dec;
12.
PMID: 39652462
About 70% of human cleavage stage embryos show chromosomal mosaicism, falling to 20% in blastocysts. Chromosomally mosaic human blastocysts can implant and lead to healthy new-borns with normal karyotypes. Studies...
4.
Krivec N, Couvreu de Deckersberg E, Lei Y, Al Delbany D, Regin M, Verhulst S, et al.
Cell Death Dis
. 2024 Nov;
15(11):852.
PMID: 39572522
Gain of 1q is a highly recurrent chromosomal abnormality in human pluripotent stem cells. In this work, we show that gains of 1q impact the differentiation capacity to derivates of...
5.
Al Delbany D, Ghosh M, Krivec N, Huyghebaert A, Regin M, Duong M, et al.
Cells
. 2024 Aug;
13(16).
PMID: 39195283
Human pluripotent stem cells (hPSCs) are pivotal in regenerative medicine, yet their in vitro expansion often leads to genetic abnormalities, raising concerns about their safety in clinical applications. This study...
6.
Lei Y, Al Delbany D, Krivec N, Regin M, Couvreu de Deckersberg E, Janssens C, et al.
Stem Cell Reports
. 2024 Mar;
19(4):562-578.
PMID: 38552632
Human pluripotent stem cell (hPSC) cultures are prone to genetic drift, because cells that have acquired specific genetic abnormalities experience a selective advantage in vitro. These abnormalities are highly recurrent...
7.
Mertens J, Belva F, van Montfoort A, Regin M, Zambelli F, Seneca S, et al.
Nat Commun
. 2024 Feb;
15(1):1232.
PMID: 38336715
Children conceived through assisted reproductive technologies (ART) have an elevated risk of lower birthweight, yet the underlying cause remains unclear. Our study explores mitochondrial DNA (mtDNA) variants as contributors to...
8.
De Bie F, Regin Y, Dubois A, Scuglia M, Arai T, Muylle E, et al.
Biomed Pharmacother
. 2023 Dec;
170:115996.
PMID: 38086148
Congenital diaphragmatic hernia (CDH) is a congenital malformation characterized by pulmonary hypoplasia, pulmonary hypertension, and cardiac dysfunction. Pulmonary hypertension represents the major cause of neonatal mortality and morbidity. Prenatal diagnosis...
9.
Regin M, Essahib W, Demtschenko A, Dewandre D, David L, Gerri C, et al.
Hum Reprod
. 2023 Jun;
38(8):1484-1498.
PMID: 37295962
Study Question: Which processes and transcription factors specify the first and second lineage segregation events during human preimplantation development? Summary Answer: Differentiation into trophectoderm (TE) cells can be initiated independently...
10.
Gerri C, McCarthy A, Mei Scott G, Regin M, Stamatiadis P, Brumm S, et al.
Development
. 2023 Mar;
150(8).
PMID: 36971487
Our understanding of the molecular events driving cell specification in early mammalian development relies mainly on mouse studies, and it remains unclear whether these mechanisms are conserved across mammals, including...