Alpha 2.0
Login Register
» Authors » Mario Mischkulnig

Mario Mischkulnig

Explore the profile of Mario Mischkulnig including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 34
Citations 405
Followers 0
Related Specialties
Oncology
Radiology
Neurosurgery
Top 10 Co-Authors
Barbara Kiesel
Georg Widhalm
Lisa I Wadiura
Julia Furtner
Thomas Roetzer
Martin Borkovec
Karl Rossler
Matthias Millesi
Adelheid Woehrer
Mitchel S Berger
Published In
Cancers (Basel)
J Neurosurg
Diagnostics (Basel)
Photodiagnosis Photodyn Ther
Neurosurg Focus
Affiliations
Soon will be listed here.
Recent Articles
1.
Analysis of the Porphyrin Peak Shift and Fluorescence Lifetime in Gliomas with Different Tumor Grades, Intratumoral Regions, and Visible Fluorescence Status
Korner L, Reichert D, Andreana M, Unterhuber A, Erkkilae M, Makolli J, et al.
Diagnostics (Basel) . 2024 Dec; 14(23). PMID: 39682559
5-aminolevulinic acid (5-ALA)-induced protoporphyrin IX (PpIX) fluorescence shows high sensitivity in detecting the tumor core of high-grade gliomas (HGG) but poor sensitivity for tissue of low-grade gliomas (LGG) and the...
2.
Detection of a Water-Soluble Hypericin Formulation in Glioblastoma Tissue with Fluorescence Lifetime and Intensity Using a Dual-Tap CMOS Camera System
Mischkulnig M, Reichert D, Wightman L, Roth V, Holz M, Korner L, et al.
Diagnostics (Basel) . 2024 Nov; 14(21). PMID: 39518390
Background: High hypericin-loaded polyvinylpyrrolidone (HHL-PVP) constitutes a novel approach to utilize the promising characteristics of hypericin for photodynamic diagnosis (PDD) and therapy (PDT) of brain tumors in an orally bioavailable...
3.
Localization of protoporphyrin IX during glioma-resection surgery via paired stimulated Raman histology and fluorescence microscopy
Nasir-Moin M, Wadiura L, Sacalean V, Juros D, Movahed-Ezazi M, Lock E, et al.
Nat Biomed Eng . 2024 Jul; 8(6):672-688. PMID: 38987630
The most widely used fluorophore in glioma-resection surgery, 5-aminolevulinic acid (5-ALA), is thought to cause the selective accumulation of fluorescent protoporphyrin IX (PpIX) in tumour cells. Here we show that...
4.
7 Tesla magnetic resonance spectroscopic imaging predicting IDH status and glioma grading
Cadrien C, Sharma S, Lazen P, Licandro R, Furtner J, Lipka A, et al.
Cancer Imaging . 2024 May; 24(1):67. PMID: 38802883
Introduction: With the application of high-resolution 3D 7 Tesla Magnetic Resonance Spectroscopy Imaging (MRSI) in high-grade gliomas, we previously identified intratumoral metabolic heterogeneities. In this study, we evaluated the potential...
5.
Where to Draw Cerebrospinal Fluid from an External Ventricular Drain? Comparison of Cerebrospinal Fluid Parameters between Two Different Collection Sites
Khalaveh F, Mischkulnig M, Zeiser V, Vossen M, Reinprecht A, Dorfer C, et al.
Diagnostics (Basel) . 2023 Dec; 13(23). PMID: 38066784
Background: High cerebrospinal fluid (CSF) sampling frequency is considered a risk factor for external ventricular drain (EVD)-associated infections. To reduce manipulation at the proximal port and potentially minimize the risk...
6.
Comparison of minimal detectable protoporphyrin IX concentrations with a loupe device and conventional 5-ALA fluorescence microscopy: an experimental study
Mischkulnig M, Traxler D, Wadiura L, Lang A, Millesi M, Kiesel B, et al.
J Biomed Opt . 2023 Nov; 28(10):106004. PMID: 37915397
Significance: The 5-aminolevulinic acid (5-ALA) fluorescence technique is now widely applied for intraoperative visualization of specific central nervous system (CNS) tumors. Previous technical implementations of this technique have relied on...
7.
Mapping high-grade glioma immune infiltration to 5-ALA fluorescence levels: TCGA data computation, classical histology, and digital image analysis
Lang A, Jeron R, Lontzek B, Kiesel B, Mischkulnig M, Berghoff A, et al.
J Neurooncol . 2023 Aug; 164(1):211-220. PMID: 37543970
Purpose: Resection of high-grade gliomas has been considerably improved by 5-aminolevulinic acid (5-ALA). However, not all neurobiological properties of 5-ALA are fully understood. Specifically, potential differences in immune infiltration have...
8.
Treatment of high-grade glioma patients during the COVID-19 pandemic: Impact on overall survival, tumor size and delay of treatment
Mischkulnig M, Hopp B, Wadiura L, Khalaveh F, Kiesel B, Rossler K, et al.
PLoS One . 2023 Jun; 18(6):e0287993. PMID: 37390078
Background: Throughout the last years, the coronavirus disease 2019 (COVID-19) pandemic posed a major challenge to the optimal and timely treatment of neurooncological patients around the world. While the importance...
9.
Toward digital histopathological assessment in surgery for central nervous system tumors using stimulated Raman histology
Wadiura L, Kiesel B, Roetzer-Pejrimovsky T, Mischkulnig M, Vogel C, Hainfellner J, et al.
Neurosurg Focus . 2022 Dec; 53(6):E12. PMID: 36455278
Objective: Intraoperative neuropathological assessment with conventional frozen sections supports the neurosurgeon in optimizing the surgical strategy. However, preparation and review of frozen sections can take as long as 45 minutes....
10.
The impact of heme biosynthesis regulation on glioma aggressiveness: Correlations with diagnostic molecular markers
Mischkulnig M, Kiesel B, Rotzer-Pejrimovsky T, Borkovec M, Lang A, Millesi M, et al.
Front Mol Neurosci . 2022 Oct; 15:928355. PMID: 36187350
Background: The prognosis of diffusely infiltrating glioma patients is dismal but varies greatly between individuals. While characterization of gliomas primarily relied on histopathological features, molecular markers increasingly gained importance and...