Mario Fraga
Overview
Explore the profile of Mario Fraga including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
1810
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0
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Recent Articles
1.
Fernandez-De-Los-Reyes I, Gomez-Dorronsoro M, Monreal-Santesteban I, Fernandez-Fernandez A, Fraga M, Azcue P, et al.
Clin Epigenetics
. 2023 Dec;
15(1):193.
PMID: 38093305
Background: Colon cancer (CC) is a heterogeneous disease that is categorized into four Consensus Molecular Subtypes (CMS) according to gene expression. Patients with loco-regional CC (stages II/III) lack prognostic factors,...
2.
Rabal O, Jose-Eneriz E, Agirre X, Sanchez-Arias J, Vilas-Zornoza A, Ugarte A, et al.
J Med Chem
. 2018 Jun;
61(15):6518-6545.
PMID: 29953809
Using knowledge- and structure-based approaches, we designed and synthesized reversible chemical probes that simultaneously inhibit the activity of two epigenetic targets, histone 3 lysine 9 methyltransferase (G9a) and DNA methyltransferases...
3.
Mueller S, Engleitner T, Maresch R, Zukowska M, Lange S, Kaltenbacher T, et al.
Nature
. 2018 Jan;
554(7690):62-68.
PMID: 29364867
The poor correlation of mutational landscapes with phenotypes limits our understanding of the pathogenesis and metastasis of pancreatic ductal adenocarcinoma (PDAC). Here we show that oncogenic dosage-variation has a critical...
4.
Mancikova V, Montero-Conde C, Perales-Paton J, Fernandez A, Santacana M, Jodkowska K, et al.
Clin Cancer Res
. 2016 Sep;
23(5):1334-1345.
PMID: 27620278
Medullary thyroid carcinoma (MTC) is a rare disease with few genetic drivers, and the etiology specific to each known susceptibility mutation remains unknown. Exploiting multilayer genomic data, we focused our...
5.
Tenorio J, Romanelli V, Martin-Trujillo A, Fernandez G, Segovia M, Perandones C, et al.
Am J Med Genet A
. 2016 Aug;
170(10):2740-9.
PMID: 27480579
Beckwith-Wiedemann syndrome (BWS) is an overgrowth syndrome characterized by an excessive prenatal and postnatal growth, macrosomia, macroglossia, and hemihyperplasia. The molecular basis of this syndrome is complex and heterogeneous, involving...
6.
Aguilera O, Munoz-Sagastibelza M, Torrejon B, Borrero-Palacios A, Del Puerto-Nevado L, Martinez-Useros J, et al.
Oncotarget
. 2016 Jun;
7(30):47954-47965.
PMID: 27323830
KRAS mutation is often present in many hard-to-treat tumors such as colon and pancreatic cancer and it is tightly linked to serious alterations in the normal cell metabolism and clinical...
7.
Salguero-Aranda C, Tapia-Limonchi R, Cahuana G, Hitos A, Diaz I, Hmadcha A, et al.
Cell Transplant
. 2016 Mar;
25(10):1879-1892.
PMID: 26980118
Pancreatic and duodenal homeobox 1 (Pdx1) is a transcription factor that regulates the embryonic development of the pancreas and the differentiation toward β cells. Previously, we have shown that exposure...
8.
Bacalini M, Gentilini D, Boattini A, Giampieri E, Pirazzini C, Giuliani C, et al.
Aging (Albany NY)
. 2015 Feb;
7(2):82-96.
PMID: 25701644
Down Syndrome (DS) is characterized by a wide spectrum of clinical signs, which include segmental premature aging of central nervous and immune systems. Although it is well established that the...
9.
Rotili D, Tarantino D, Nebbioso A, Paolini C, Huidobro C, Lara E, et al.
J Med Chem
. 2012 Nov;
55(24):10937-47.
PMID: 23189967
Chemical changes performed on 1a (sirtinol) led to a series of SIRT1/2 inhibitors, in some cases more potent than 1a mainly against SIRT1. Tested in human leukemia U937 cells, the...
10.
Garcia-Carpizo V, Ruiz-Llorente L, Fraga M, Aranda A
J Mol Endocrinol
. 2011 Aug;
47(2):R75-89.
PMID: 21803863
DNA methylation is the best studied epigenetic factor, playing a key role in producing stable changes in gene expression, thus defining cell identity and function and adapting cells to environmental...