Marina Iskhakova
Overview
Explore the profile of Marina Iskhakova including associated specialties, affiliations and a list of published articles.
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11
Citations
120
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Recent Articles
1.
Clarence T, Bendl J, Cao X, Wang X, Zheng S, Hoffman G, et al.
Nat Genet
. 2025 Feb;
57(3):591-603.
PMID: 39962241
Human brain development spans from embryogenesis to adulthood, with dynamic gene expression controlled by cell-type-specific cis-regulatory element activity and three-dimensional genome organization. To advance our understanding of postnatal brain development,...
2.
Wei J, Lambert T, Valada A, Patel N, Walker K, Lenders J, et al.
Nat Commun
. 2023 Sep;
14(1):5610.
PMID: 37699936
Dynamic interactions of neurons and glia in the ventral midbrain mediate reward and addiction behavior. We studied gene expression in 212,713 ventral midbrain single nuclei from 95 individuals with history...
3.
Wei J, Lambert T, Valada A, Patel N, Walker K, Lenders J, et al.
bioRxiv
. 2023 Mar;
PMID: 36945611
Dynamic interactions of neurons and glia in the ventral midbrain (VM) mediate reward and addiction behavior. We studied gene expression in 212,713 VM single nuclei from 95 human opioid overdose...
4.
Plaza-Jennings A, Valada A, OShea C, Iskhakova M, Hu B, Javidfar B, et al.
Mol Cell
. 2022 Dec;
82(24):4647-4663.e8.
PMID: 36525955
To explore genome organization and function in the HIV-infected brain, we applied single-nuclei transcriptomics, cell-type-specific chromosomal conformation mapping, and viral integration site sequencing (IS-seq) to frontal cortex from individuals with...
5.
Sey N, Hu B, Iskhakova M, Lee S, Sun H, Shokrian N, et al.
Mol Psychiatry
. 2022 Jul;
27(10):4368.
PMID: 35794187
No abstract available.
6.
Sey N, Hu B, Iskhakova M, Lee S, Sun H, Shokrian N, et al.
Mol Psychiatry
. 2022 Apr;
27(7):3085-3094.
PMID: 35422469
Cigarette smoking and alcohol use are among the most prevalent substances used worldwide and account for a substantial proportion of preventable morbidity and mortality, underscoring the public health significance of...
7.
Corradin O, Sallari R, Hoang A, Kassim B, Ben Hutta G, Cuoto L, et al.
Mol Psychiatry
. 2022 Mar;
27(4):2158-2170.
PMID: 35301427
Opioid use disorder is a highly heterogeneous disease driven by a variety of genetic and environmental risk factors which have yet to be fully elucidated. Opioid overdose, the most severe...
8.
Neuron-specific chromosomal megadomain organization is adaptive to recent retrotransposon expansions
Chandrasekaran S, Espeso-Gil S, Loh Y, Javidfar B, Kassim B, Zhu Y, et al.
Nat Commun
. 2021 Dec;
12(1):7243.
PMID: 34903713
Regulatory mechanisms associated with repeat-rich sequences and chromosomal conformations in mature neurons remain unexplored. Here, we map cell-type specific chromatin domain organization in adult mouse cerebral cortex and report strong...
9.
Induction of dopaminergic neurons for neuronal subtype-specific modeling of psychiatric disease risk
Powell S, OShea C, Townsley K, Prytkova I, Dobrindt K, Elahi R, et al.
Mol Psychiatry
. 2021 Sep;
28(5):1970-1982.
PMID: 34493831
Dopaminergic neurons are critical to movement, mood, addiction, and stress. Current techniques for generating dopaminergic neurons from human induced pluripotent stem cells (hiPSCs) yield heterogenous cell populations with variable purity...
10.
Dobrindt K, Hoagland D, Seah C, Kassim B, OShea C, Murphy A, et al.
Stem Cell Reports
. 2021 Feb;
16(3):505-518.
PMID: 33636110
The host response to SARS-CoV-2, the etiologic agent of the COVID-19 pandemic, demonstrates significant interindividual variability. In addition to showing more disease in males, the elderly, and individuals with underlying...