Marian Ludgate
Overview
Explore the profile of Marian Ludgate including associated specialties, affiliations and a list of published articles.
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55
Citations
1133
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Recent Articles
1.
Razvi S, Wild H, Ingoe L, Vernazza J, Vanderpump M, Pearce S, et al.
J Clin Endocrinol Metab
. 2024 Dec;
PMID: 39673773
Background: Longitudinal studies of thyroid function have demonstrated differing results. It remains unclear whether changes in thyroid function affect the diagnosis of subclinical thyroid dysfunction with ageing. Methods: Survivors of...
2.
Scholz A, McNabb C, Bloomfield L, Bhargava R, Hales C, Dayan C, et al.
J Clin Endocrinol Metab
. 2024 May;
PMID: 38747483
Context: Children born to mothers with gestational hypo- or hyperthyroidism may have increased risk of adverse neurodevelopmental outcomes. However, the effects of maternal thyroid status on offspring brain development are...
3.
Biscarini F, Masetti G, Muller I, Verhasselt H, Covelli D, Colucci G, et al.
J Clin Endocrinol Metab
. 2023 Jan;
108(8):2065-2077.
PMID: 36683389
Context: Gut bacteria can influence host immune responses but little is known about their role in tolerance-loss mechanisms in Graves disease (GD; hyperthyroidism caused by autoantibodies, TRAb, to the thyrotropin...
4.
Zhou H, Muller I, Chong K, Ludgate M, Fang S
Front Endocrinol (Lausanne)
. 2022 May;
13:902591.
PMID: 35574000
No abstract available.
5.
Draman M, Zhang L, Dayan C, Ludgate M
Front Endocrinol (Lausanne)
. 2021 Dec;
12:739994.
PMID: 34899596
Graves' orbitopathy (GO) is a complex and poorly understood disease in which extensive remodeling of orbital tissue is dominated by adipogenesis and hyaluronan production. The resulting proptosis is disfiguring and...
6.
Draman M, Grennan-Jones F, Taylor P, Muller I, Evans S, Haridas A, et al.
Curr Issues Mol Biol
. 2021 Dec;
43(3):1794-1804.
PMID: 34889904
Thyroid stimulating antibodies (TSAB) cause Graves' disease and contribute to Graves' Orbitopathy (GO) pathogenesis. We hypothesise that the presence of TSH binding proteins (truncated variants ()) and/or nonclassical ligands such...
7.
Candler T, Kessler N, Gunasekara C, Ward K, James P, Laritsky E, et al.
Sci Adv
. 2021 Nov;
7(45):eabj1561.
PMID: 34739318
PAX8 is a key thyroid transcription factor implicated in thyroid gland differentiation and function, and gene methylation is reported to be sensitive to the periconceptional environment. Using a novel recall-by-epigenotype...
8.
Zhang L, Rai P, Miwa S, Draman M, Aled Rees D, Haridas A, et al.
Endocrinology
. 2021 Sep;
162(12).
PMID: 34473251
Context: Depot-specific expansion of orbital adipose tissue (OAT) in Graves orbitopathy (GO; an autoimmune condition producing proptosis, visual impairment and reduced quality of life) is associated with fatty acid (FA)-uptake-driven...
9.
Hepp M, Werion A, De Greef A, de Ville de Goyet C, de Bournonville M, Behets C, et al.
Int J Mol Sci
. 2021 Apr;
22(8).
PMID: 33916948
In Hashimoto's thyroiditis (HT), oxidative stress (OS) is driven by Th1 cytokines' response interfering with the normal function of thyrocytes. OS results from an imbalance between an excessive production of...
10.
Moshkelgosha S, Verhasselt H, Masetti G, Covelli D, Biscarini F, Horstmann M, et al.
Microbiome
. 2021 Feb;
9(1):45.
PMID: 33593429
Background: Graves' disease (GD) is an autoimmune condition in which autoantibodies to the thyrotropin receptor (TSHR) cause hyperthyroidism. About 50% of GD patients also have Graves' orbitopathy (GO), an intractable...